PhD in Enabling Antibiotics Discovery by Targeted Protein Degradation The Francis Crick Institute in United Kingdom

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...

PhD opportunity at The Francis Crick Institute, London, United Kingdom in regulatory switching of a microtubule motor-scaffold complex with Dr Sami Chaaban. This funded PhD project focuses on how microtubule motors , especially kinesins , organize microtubules and position regulatory proteins during cell division. The project asks how interactions with regulatory partners switch kinesins between functional states and how these changes shape specialized microtubule structures. Research methods in...

Funded PhD project at The Francis Crick Institute in London, United Kingdom, with Dr Frank Uhlmann and the Chromosome Segregation Laboratory. The project, Chromosome Organisation by Dynamic Cohesin Complexes , focuses on chromosome organisation , cohesin , chromatin loops , topologically associating domains , and the broader mechanisms of genome organisation and chromosome segregation . The lab studies how Structural Maintenance of Chromosome (SMC) complexes support sister chromatid cohesion, ch...

PhD opportunity: In situ structural biology of cellular adaptation at The Francis Crick Institute in collaboration with University College London . This 2027 joint PhD project is supervised by Dr Peter Rosenthal (Crick) and Dr Amandine Maréchal (UCL). The project sits at the interface of structural biology , mitochondrial biology , bioenergetics , cell biology , microbiology , biochemistry , and biophysics . The research asks how cells adapt to environmental and metabolic stress by remodeling th...

PhD opportunity at The Francis Crick Institute in virology, cell biology, biochemistry, biophysics, and structural biology , focused on signalling and cytoskeletal regulation during Vaccinia virus egress . The Way lab uses Vaccinia virus as a model system to study how viruses exploit host-cell machinery during replication, assembly, transport, and release. This project investigates unanswered questions in viral egress, including how intracellular mature virions recruit molecular motors, how viri...