PhD in Single-Cell Multi-Omics and Enhancer Control of Blood and Cardiovascular Fate University of East Anglia in United Kingdom

Funded PhD opportunity at the MRC Laboratory of Medical Sciences (LMS) in London, United Kingdom, on spatial and three-dimensional genome regulation during zygotic genome activation (ZGA) . This project explores how chromatin architecture, promoter-enhancer communication, boundary formation, insulation, and spatially restricted transcriptional states are coordinated as the embryonic genome becomes active. The work sits at the intersection of developmental genomics , chromatin biology , genomics ...

PhD opportunity at The Francis Crick Institute with Dr Ekaterina Osipova on genetic mechanisms of metabolic rate control in birds and mammals . This project focuses on how metabolic rate varies across animals and how genetic elements, genes, and regulatory regions shape those differences. The work combines comparative genomics , evolution , genomics , bioinformatics , molecular genetics , and potentially lab-based validation . The lab uses evolutionary rate-based methods and machine-learning app...

PhD opportunity in human embryology, developmental biology, genomics, cell biology, human genetics and molecular biology at the Medical Research Council (Cambridge) Laboratory of Molecular Biology in the United Kingdom . This project, supervised by Dr M Shahbazi with co-supervision from Roser Vento-Tormo at the Wellcome Sanger Institute , asks a fundamental question in early human development: where do cells go in the human embryo? The research focuses on the first two weeks of development, when...

Funded PhD project at the MRC Laboratory of Medical Sciences (LMS) in London, United Kingdom on reading tissue history and exposures using spatial single-cell genomics . The project is based in the newly established Tissue Biology Group and focuses on building and applying technologies that can read cellular history while preserving spatial context in intact human tissue. Research themes include spatial lineage tracing , single-cell and spatial genomics , DNA methylation , somatic mutations , ex...

PhD opportunity at the University of Oxford in the Department of Paediatrics on developing a precision RNA editing platform for therapeutic applications . This funded DPhil project focuses on RNA editing , antisense oligonucleotides (ASOs) , genetics , genomics , molecular biology , molecular genetics , and cell biology . The project aims to identify disease-causing mutations amenable to RNA editing, engineer ASO conjugates that target endogenous RNA editors, and test lead candidates in reporter...