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École Polytechnique Fédérale de Lausanne

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PhD Position in Macrocyclic Kinase Inhibitor Development at EPFL École polytechnique fédérale de Lausanne in Switzerland

Degree Level

PhD

Field of study

Chemistry

Funding

Full funding available
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Country

Switzerland

University

École Polytechnique Fédérale de Lausanne

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Keywords

Chemistry
Biomedical Engineering
Biology
Peptide Chemistry
High-throughput Screening
Chemical Biology
Pharmacy
Combinatorial Chemistry

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About this position

PhD position available at EPFL (École polytechnique fédérale de Lausanne) in Lausanne, Switzerland, in the group of Christian Heinis. The project is part of the European Doctoral Network ANA-KIN and focuses on macrocyclic kinase inhibitor development.

The research will explore the discovery of macrocyclic inhibitors that target regulatory interfaces of disease-relevant kinases beyond the conserved ATP-binding site. The PhD student will work on the design and synthesis of large combinatorial libraries of macrocyclic compounds, development of high-throughput screening strategies, and identification/characterization of new kinase ligands.

This is an interdisciplinary opportunity at the interface of chemistry, chemical biology, biochemistry, pharmaceutical sciences, and screening/automation methods, with collaboration and training across academic and industrial partners in the ANA-KIN network.

Applicants should have a background in chemistry, biochemistry, chemical biology, pharmaceutical sciences, or a related field. Experience in peptide synthesis, molecular biology, high-throughput screening, or laboratory automation is welcome but not required.

The position is fully funded. The post indicates a starting date in the first half of 2027. Interested candidates should send a CV, a short motivation letter, and a list of references to [email protected]. More details are available via the linked PDF and short link.

Funding details

Full funding including tuition fees and living expenses is available for this position. The scholarship covers all educational costs and provides a monthly stipend.

How to apply

Please submit your application including a cover letter, CV, academic transcripts, and contact information for two references. Applications should be sent via the online portal before the deadline.

More information can be found here

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