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Anne Smits

Top university

1 month ago

PhD Position in Neonatal Clinical Pharmacology: Drug Exposure-Response Modelling in Critically Ill Neonates KU Leuven in Belgium

Degree Level

PhD

Field of study

Biology

Funding

Available

Deadline

Sep 28, 2026

Country flag

Country

Belgium

University

KU Leuven

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Keywords

Biology
Neonatology
Pharmacometrics
Pediatric Pharmacology

About this position

KU Leuven is offering a PhD position in neonatal clinical pharmacology focused on drug exposure-response modelling in critically ill neonates.

This project is part of a research line in developmental pharmacology and is carried out in collaboration between the Department of Development and Regeneration, the Department of Pharmaceutical and Pharmacological Sciences, and the Neonatal Intensive Care Unit of University Hospitals Leuven. The aim is to improve understanding of how commonly used medicines affect critically ill newborns by combining real-world neonatal datasets, advanced bedside neuro-monitoring, and modern pharmacometric methods.

The research will concentrate on neuroactive and analgesic/sedative drugs including doxapram, fentanyl, and dexmedetomidine. The successful candidate will analyze pharmacokinetic and clinical datasets, integrate drug concentrations with pharmacodynamic endpoints and cerebral monitoring data, and develop population PKPD and/or physiologically based PK-PD models. The work is intended to characterize exposure-response relationships and support better evidence-based dosing in neonates.

The PhD candidate will join an interdisciplinary environment involving clinicians, pharmacologists, pharmacometricians, and engineers. Activities include literature review on developmental cerebral pharmacodynamics, model development and evaluation, scientific writing, conference presentations, and publication in peer-reviewed journals. The project also includes support for writing an FWO PhD fellowship proposal.

Applicants should hold a relevant master’s degree in fields such as Pharmaceutical Sciences, Biomedical Sciences, Medicine, Drug Development, Bioengineering, Statistics, or Applied Mathematics. A strong interest in clinical pharmacology, pharmacometrics, translational research, and quantitative modelling is essential. Experience with PK, PKPD, PBPK, NONMEM, Monolix, Simcyp, nlmixr, R, MATLAB, or Python is considered an advantage.

The position is a four-year PhD at KU Leuven, with an evaluation after the first year. The trajectory is expected to start at the end of October 2026. KU Leuven highlights access to unique neonatal datasets, advanced monitoring infrastructure, training in pharmacometrics and neonatal research, and an internationally recognized multidisciplinary research setting in Leuven, Belgium.

Funding details

Available

What's required

A Master's degree in Pharmaceutical Sciences, Biomedical Sciences, Medicine, Drug Development, Bioengineering, Statistics, Applied Mathematics or a related discipline is required. Applicants should have a strong interest in clinical pharmacology, pharmacometrics and translational research, excellent analytical and problem-solving skills, affinity for quantitative data analysis and modelling, excellent written and spoken English, and the ability to work independently as well as within an interdisciplinary team. Strong assets include experience in pharmacometrics, population PK, PKPD or PBPK modelling, use of NONMEM, OSP Suite, Monolix, Simcyp, nlmixr or similar platforms, programming in R, MATLAB and/or Python, and analysis of physiological or biomedical data.

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Professors

Prof. dr. at KU Leuven

University Name
Country flag

Belgium

Research Interests

Pediatric Nutrition

Maternal And Child Health

Clinical Chemistry

Neonatology

Pharmacokinetic

Prof. dr. at KU Leuven

University Name
Country flag

Belgium

Research Interests

Pharmacometrics

Neonatology

Pediatric Pharmacology

Biology

Prof. dr. at KU Leuven

University Name
Country flag

Belgium

Research Interests

Pediatric Nutrition

Clinical Nutrition

Neonatology

Therapeutic Hypothermia

Pediatric Cardiology