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Roger Schibli

3 months ago

PhD Position in Radiopharmaceutical Sciences: Glycoengineered Peptides and Nanobodies for Imaging and Therapy ETH Zürich in Switzerland

Degree Level

PhD

Field of study

Chemistry

Funding

Available

Country flag

Country

Switzerland

University

ETH Zürich

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Keywords

Chemistry
Biology
Peptide Chemistry
Radiochemistry
Glycobiology
Medical Science
Molecular Imaging
Pharmacy
Protein Engineering
Pet Imaging
Radiopharmaceutical Chemistry
Spectral Imaging
Preclinical Imaging
Pharmacokinetic
Pharmacodynamic

About this position

ETH Zurich and the Paul Scherrer Institute are offering a funded PhD position in radiopharmaceutical sciences within the Center for Radiopharmaceutical Sciences (CRS), a joint research center internationally recognized for pioneering work in radiopharmaceutical chemistry and targeted radionuclide therapy.

The project is hosted by the Schibli Group, led by Prof. Roger Schibli, in close collaboration with the laboratory of Prof. Kaspar Locher in the Department of Biology at ETH Zurich. The research focuses on glycoengineered peptides and nanobodies for imaging and therapy, with an emphasis on understanding how defined N-glycosylation can improve pharmacokinetic and pharmacological behavior. This is a translational project connecting glycobiology, molecular imaging, radiochemistry, and preclinical evaluation.

As a PhD student, you will develop and optimize radiolabeling strategies for glycosylated peptides and nanobodies, perform quality control and analytical characterization, conduct cell-based binding and uptake studies, and plan and analyze biodistribution, PET, and SPECT imaging in mouse models. You will also investigate pharmacokinetic and pharmacodynamic properties of novel radiolabeled compounds and collaborate closely with a PhD student in the Locher laboratory to optimize glycosylated constructs.

The position is well suited to candidates with a strong background in chemistry, pharmaceutical sciences, biochemistry, molecular biology, or biotechnology, and with interest or experience in radiopharmaceutical sciences, radiochemistry, bioconjugation, protein engineering, cell biology, or preclinical imaging. Experience with PET/SPECT imaging, radiopharmacy, or animal studies is welcome but not required. Strong English communication skills, independence, and teamwork in an interdisciplinary and international environment are important.

The position is supported by a newly funded interdisciplinary ETH research project. ETH Zurich offers access to state-of-the-art infrastructure, mentoring, training opportunities, and a collaborative research culture. Applications must be submitted online and should include a motivation letter, CV, academic records and degree certificates, a summary of research projects, and contact details for at least two academic referees. For scientific enquiries, contact Dr. Martin Béhé at [email protected]. More information about CRS is available at https://radiopharmaceutical-science.ethz.ch/ and https://www.psi.ch/en/crs.

Funding details

Available

What's required

Applicants should hold a Master's degree with an excellent academic record in Chemistry, Pharmaceutical Sciences, Biochemistry, Molecular Biology, Biotechnology, or a related discipline. Strong interest in radiopharmaceutical sciences, molecular imaging, protein engineering, glycobiology, or bioconjugation chemistry is expected. Practical experience in radiochemistry or radiopharmacy, cell biology and cell culture, protein or peptide chemistry, or preclinical in vivo research is an advantage. Excellent organizational and problem-solving skills are required, along with the ability to work independently and collaboratively in an interdisciplinary and international environment. Excellent written and oral communication skills in English are required. Prior experience in radiopharmaceutical research, PET/SPECT imaging, or animal studies is considered an advantage but is not required.

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Professors

Prof. at ETH Zürich

University Name
Country flag

Switzerland

Research Interests

Pharmacology

Pharmaceutical Chemistry

Radiopharmaceutical Chemistry

Molecular Imaging

Preclinical Imaging

Prof. at ETH Zürich

University Name
Country flag

Switzerland

Research Interests

Biochemistry

Pharmacology

Glycobiology

Chemical Biology

Protein Chemistry