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University of Birmingham
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PhD Studentship: CENTA 2027-B05 Novel ways to deal with the complexities of detecting selection for antimicrobial resistance under realistic natural conditions University of Birmingham in United Kingdom
Degree Level
PhD
Field of study
Environmental Science
Funding
Available
Deadline
Jan 6, 2027
Country
United Kingdom
University
University of Birmingham
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About this position
This PhD studentship addresses a major question in antimicrobial resistance research: whether low antibiotic concentrations in the environment can select for resistance under realistic natural conditions. The project is designed around a combination of laboratory experiments, mathematical modelling, and environmental validation.
The research begins with simple competition experiments between matched sensitive and resistant bacteria, allowing the student to examine how selection changes across antibiotic concentrations when the only major difference between strains is resistance. The project then builds mathematical models to incorporate the complications that make natural environments difficult to study directly, including diversity, predation, low substrate concentrations, and other ecological factors.
A key part of the studentship is testing and validating the model in more natural settings. This will involve flume mesocosms that mimic river conditions in the laboratory at UKCEH Wallingford, as well as in situ experiments in rivers. The bacteria of interest will be placed in dialysis bag “cages” so they remain exposed to the surrounding environmental conditions while being retained in place, enabling the study of selection without the organisms escaping into the environment.
The project is offered through the CENTA3 Doctoral Landscape Award and is based at the University of Birmingham, with environmental experimentation linked to UKCEH Wallingford and river systems. It is aimed at creating a validated predictive framework for understanding when selection for antimicrobial resistance occurs in complex environmental settings.
Funding details
Available
What's required
Applicants should have at least a UK 2:1 BSc degree or a pass at UK MSc level, or equivalent. International applicants must meet the University of Birmingham’s international student entry requirements, including English language requirements. International students are eligible for studentships up to 30% of the cohort.
How to apply
Click the Apply button on the studentship page to start the application. For general CENTA studentship application guidance, consult the CENTA website. Review the University of Birmingham international student requirements if applicable.
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