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University of Birmingham
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PhD Studentship: CENTA 2027-B06 Combatting Insecticide Pollution: An Evolution-Informed Molecular Docking Framework to Protect Pollinators and Beneficial Insects University of Birmingham in United Kingdom
Degree Level
PhD
Field of study
Computer Science
Funding
Available
Deadline
Jan 6, 2027
Country
United Kingdom
University
University of Birmingham
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About this position
This PhD project addresses a major environmental challenge: how to reduce unintended harm from insecticides to pollinators, predators, parasitoids, and other beneficial insects. The research is framed around the idea that many broad-spectrum insecticides act on conserved molecular targets across the arthropod tree of life, creating shared vulnerability across species through evolutionary relatedness. The project will use that evolutionary signal to build a predictive framework for assessing species-specific susceptibility.
The student will compile target-protein sequences spanning five major insecticide classes and a phylogenetically representative set of pest and beneficial arthropods. These sequences will be used to generate structural models, refine them with homology modelling and AlphaFold, and then test environmentally relevant insecticides through molecular docking pipelines. The aim is to connect sequence and structural divergence with differential binding and likely susceptibility across species.
The project combines comparative biology, structural modelling, and computational toxicology, and it will be benchmarked against published resistance and species-sensitivity data. Experimental validation will be carried out in Drosophila melanogaster and cell-based assays, helping to connect in silico predictions with laboratory evidence. The broader output is a species-risk prioritisation framework and a cheminformatics tool intended to help identify at-risk species and support safer insecticide selection.
The work is hosted at the University of Birmingham and offered through CENTA3, with an industrial partner involved in the later case-study stage. The project is structured over 3.5 years, moving from phylogenomic data assembly and structural modelling into docking pipeline development, benchmarking, experimental validation, and final synthesis and dissemination.
Funding details
Available
What's required
Applicants should have at least a 2:1 at UK BSc level or a pass at UK MSc level, or an equivalent qualification. International applicants must meet the international student entry requirements, including English language requirements.
How to apply
Click the Apply button on the project page to apply. Further guidance on applying for a CENTA studentship is available on the CENTA website. International applicants should also review the University of Birmingham international entry requirements before applying.
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