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Graeme Kettles

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PhD Studentship: Designing synthetic proteins for sustainable control of fungal plant diseases University of Birmingham in United Kingdom

Degree Level

PhD

Field of study

Computer Science

Funding

Available

Deadline

Nov 23, 2026

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Country

United Kingdom

University

University of Birmingham

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Keywords

Computer Science
Chemistry
Environmental Science
Agriculture
Biomedical Engineering
Biology
Protein Engineering
Protein-protein Interaction
Plant Immunity

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About this position

[PhD studentship funded by BBSRC through the Midlands Integrated Biosciences Training Partnership, in partnership with the University of Warwick, University of Birmingham, Aston University, Harper Adams University, Coventry University, and the University of Leicester.]

This PhD studentship at the University of Birmingham focuses on designing synthetic proteins for the sustainable control of fungal plant diseases. The project sits at the interface of plant pathology, protein engineering, and AI-driven molecular design, and it aims to create new protein-based tools that help plants resist fungal pathogens.

Fungal pathogens secrete effector proteins to suppress host defences, but these same effectors can also be vulnerabilities if they are recognised or blocked. In this project, the student will use modern computational protein design approaches to develop synthetic proteins that either bind fungal effectors and neutralise their function or can be incorporated into immune receptors to expand the plant’s ability to recognise disease-causing proteins.

The work will build on a set of immune-suppressing effectors already identified from the wheat pathogen Zymoseptoria tritici. The student will learn and apply computational protein design pipelines such as RFdiffusion and BindCraft, then produce both target effectors and designed proteins in bacterial, yeast, and insect expression systems. Protein-protein interactions will be tested in vitro using isothermal titration calorimetry (ITC) or microscale thermophoresis (MST) in collaboration with Prof. Andy Lovering’s lab. Promising interactions will then be evaluated in plants using Agrobacterium-mediated transient expression in Nicotiana benthamiana.

This is a highly interdisciplinary project with strong training in protein design, molecular interaction analysis, and plant-based functional assays. It is framed as a proof-of-concept study showing that AI-designed synthetic proteins can be used to disrupt pathogen effector function or support the creation of new immune receptors for improved crop protection.

The position is part of a PhD studentship within the Midlands Integrated Biosciences Training Partnership, funded by BBSRC and involving the University of Warwick, University of Birmingham, Aston University, Harper Adams University, Coventry University, and the University of Leicester. No funding amount is specified in the advert. The application deadline is 23 November 2026, and applicants should use the University of Birmingham application portal. Informal enquiries may be directed to Dr Graeme Kettles at [email protected].

Funding details

Available

What's required

Applicants should be interested in computational protein design, molecular biology, and plant pathology. The project will involve learning AI-based protein design pipelines (for example RFdiffusion and BindCraft), producing proteins in bacterial, yeast, and insect expression systems, and working with protein interaction assays such as ITC or MST, plus Agrobacterium-mediated transient expression in Nicotiana benthamiana. No specific degree classification, language test, or prior experience is explicitly stated in the post.

How to apply

Apply through the University of Birmingham application portal using the provided course link. Review the Midlands Integrative Biosciences Training Partnership pages for further project and application details. For informal enquiries, contact Dr Graeme Kettles by email.

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Professors

Prof. at University of Birmingham

University Name
Country flag

United Kingdom

Research Interests

Protein-protein Interaction

Plant Immunity

Environmental Science

Biology

Computer Science