PhD Studentship in Designing Peptides to Uncover Cancer Vulnerabilities at Telomeres MRC Laboratory of Medical Sciences in United Kingdom

Funded PhD project at the University of Bristol in the School of Biochemistry and Biomedical Sciences, focused on β-lactamase-mediated antibiotic resistance , biomolecular simulation , enzyme kinetics , and X-ray crystallography . The project investigates how class C β-lactamases break down cephalosporin antibiotics and how diazabicyclooctanone (DBO) inhibitors block these enzymes. The research combines computational chemistry, structural biology, molecular biology/biochemistry, and kinetic expe...

Funded PhD project at the University of Bristol in the School of Biochemistry and Biomedical Sciences on PINK1 , mitochondrial quality control , and Parkinson’s disease . The project, supervised by Prof I Collinson and Dr Robin Corey , investigates how PINK1 switches between alternative fates in mitochondria: matrix import versus cleavage/retro-translocation and outer-membrane activation. The research combines biochemistry , biophysics , cell biology , and computational modelling to study the co...

Funded PhD opportunity at Coventry University in the Centre for Discoveries in Life Science, within the Midlands Integrative Biosciences Training Partnership (MIBTP). This project focuses on intracellular pathways , GPCR signalling , anthracycline treatment , and the molecular mechanisms behind drug-induced vascular injury (DIVI). The research aims to understand how anti-cancer drugs such as doxorubicin alter GPCRs and downstream signalling pathways, with a translational goal of widening the ran...

PhD opportunity at the University of Leicester in AI-designed binders, secretome research, and discovery proteomics . This funded CASE PhD project explores whether AI-designed mini-binders can be made selective enough to recognize the right protein target in complex biological samples. The work focuses on the secretome and aims to create new tools for discovery science and future diagnostics. You will use existing proteomic datasets to identify secreted proteins of interest, design binders with ...

Funded PhD project at the University of Bristol in the School of Biochemistry and Biomedical Sciences with Dr Maisem Laabei on targeted covalent macrocycles for immune-mediated diseases . The project focuses on the complement system and pathway-specific inhibition of key serine proteases, especially C1s and factor D , to develop more selective therapies for inflammatory and autoimmune conditions. Research themes include biochemistry , molecular biology , microbiology , phage display , chemical s...