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Gi Fay Mok

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PhD Studentship: One Cell at a Time: Uncovering Enhancer Control of Blood and Cardiovascular Fate Using Single-cell Multi-omics University of East Anglia in United Kingdom

Degree Level

PhD

Field of study

Computer Science

Funding

Available

Deadline

Nov 30, 2026

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Country

United Kingdom

University

University of East Anglia

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Keywords

Computer Science
Biomedical Engineering
Biology
Computational Biology
Developmental Biology
Medical Science
Statistics

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About this position

[4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD studentship including tuition fees paid directly to the University, a stipend for living expenses (£21,805 for 2026/27), and a Research Training Support Grant of £5,000 per year.]

This PhD studentship explores how enhancers control the emergence of blood, vascular, and cardiac cell fates during vertebrate development. Using the chick embryo as a model, the project focuses on how gene-regulatory programmes shape the transition from shared mesodermal progenitors to distinct cardiovascular lineages.

The student will combine single-cell RNA-sequencing and ATAC-sequencing to track changes in gene expression and chromatin accessibility as blood, endothelial, and cardiac lineages emerge. A major aim is to identify candidate enhancers linked to specific cell states and developmental trajectories, with particular attention to hematoendothelial progenitors that generate the first blood and vascular cells.

The project also includes experimental validation of enhancer function. Candidate enhancers will be cloned into fluorescent reporter constructs and their activity visualised in living embryos. Selected elements will then be tested through CRISPR-based perturbation and motif mutagenesis to assess their effects on gene expression, cell behaviour, and fate decisions in vivo.

The student will join a collaborative supervisory team across the University of East Anglia and the Earlham Institute, working with Dr Gi Fay Mok, Professor Andrea Münsterberg, Dr Iain Macaulay, and Dr Wilfried Haerty. The project offers interdisciplinary training spanning developmental biology, molecular genetics, imaging, single-cell genomics, and computational biology.

Funding details

Available

What's required

No specific degree classification, GPA, or English language test requirements are stated in the advert. The project is suitable for candidates interested in developmental biology, molecular genetics, imaging, single-cell genomics, and computational biology, and it involves both computational and experimental work.

How to apply

Click the Apply button on the University of East Anglia advert page to submit your application. For questions about the project, contact [email protected].

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Professors

Professor at University of East Anglia

University Name
Country flag

United Kingdom

Research Interests

Statistics

Developmental Biology

Computational Biology

Biology

Medical Science