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CNRS
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Post-doctoral Researcher in RNA and Translation CNRS in France
Degree Level
Postdoc
Field of study
Biochemistry
Funding
Available
Deadline
Dec 1, 2026
Country
France
University
CNRS
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About this position
This postdoctoral position is part of the ERC Synergy project 3Stops2go, a collaborative effort bringing together four teams working on alternative decoding for therapeutic purposes.
At the I2BC, the project focuses on two complementary research directions. First, the postdoctoral researcher will help design, implement, and analyse a large-scale screen in human cells to identify new suppressor tRNAs able to read premature termination codons efficiently while maintaining strong selectivity against native stop codons. Second, the project seeks to clarify the mechanism of action of TLN468 and related derivatives, compounds identified by the team as readthrough inducers with a distinct selectivity profile for the amino acid incorporated at each stop codon.
The successful candidate will contribute to key project deliverables through the design of quantitative reporters, execution of functional screens, high-throughput data analysis, and mechanistic interpretation of results. The work combines molecular biology, biochemistry, cell-based assays, and analysis of sequencing and ribosome-profiling data.
The position is hosted at the I2BC in Gif-sur-Yvette within the Génomique, Structure et Traduction team, which studies translation, ribosome dynamics, and stop-codon readthrough. The postdoctoral researcher will work in an environment supported by institutional platforms in sequencing, cytometry, mass spectrometry, and cryo-EM, and will interact with collaborators from the ERC consortium.
Funding details
Available
How to apply
Apply through the official job posting link. Submit the application materials requested on the portal before the deadline.
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Make your next move.
Prepare your application
Review drafts and confirm requirements with the university.