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University of Southern Denmark

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Postdoc in Intestinal Regeneration and Mucosal Immunology University of Southern Denmark in Denmark

Degree Level

Postdoc

Field of study

Computer Science

Funding

Full-time postdoctoral position for two years, with possibility of extension subject to funding. Salary is according to the Danish state salary scale, salary steps 4–8, with a centrally agreed postdoc allowance and possible further qualification- and function-related allowances.

Deadline

Nov 15, 2026

Country flag

Country

Denmark

University

University of Southern Denmark

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Keywords

Computer Science
Biology
Inflammatory Bowel Disease
Medical Science
Mucosal Immunology
Epigenetic
Fibroblast Biology
Epithelial Biology
Bioinformatic
Spatial Transcriptomic

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About this position

This postdoctoral project at the University of Southern Denmark focuses on how inflammatory history reshapes the intestinal epithelium and its surrounding niche, and how these changes influence mucosal healing in inflammatory bowel disease. The work sits at the interface of intestinal tissue regeneration, epithelial biology and mucosal immunology, with a translational emphasis on understanding why some healing responses are effective while others fail.

The successful candidate will join the lab of Dr. Srustidhar Das within the Department of Clinical Research and the Research Unit of Inflammation Research in the Department of Molecular Medicine, Faculty of Health Sciences. The postdoc will work in a collaborative environment that connects basic scientists, clinicians, bioinformaticians and translational researchers, with strong links to Odense University Hospital and access to patient-derived material, advanced disease models and modern molecular technologies.

The project combines patient-derived biopsies, intestinal organoids, fibroblasts and immune-cell co-cultures to investigate epithelial plasticity, injury-induced cell-state transitions and regenerative capacity. A major part of the work is to trace how epithelial memory and niche interactions shape repair, using functional assays alongside single-cell and spatial genomics. The project also uses CRISPR-engineered patient-derived organoids, including reporter lines and targeted perturbations, to validate candidate mechanisms and test whether regenerative phenotypes can be translated into improved tissue integration and repair in vivo.

The position is research-intensive and also includes teaching, professional development and supervision. It is well suited to a candidate who wants to connect experimental biology with computational analysis and clinically relevant questions in a highly interdisciplinary research setting.

Funding details

Full-time postdoctoral position for two years, with possibility of extension subject to funding. Salary is according to the Danish state salary scale, salary steps 4–8, with a centrally agreed postdoc allowance and possible further qualification- and function-related allowances.

What's required

Applicants must hold a PhD in molecular biology, cell biology, immunology, bioinformatics, computational biology, regenerative medicine, biomedicine or a closely related discipline, with documented research experience relevant to the project. Essential requirements include documented experience in organoid biology, preferably intestinal or other tissue-derived epithelial organoids, a strong background in tissue regeneration, epithelial biology, mucosal immunology or inflammatory disease, demonstrated expertise in single-cell or spatial-omics analysis with proficiency in R and/or Python and reproducible computational workflows, hands-on molecular and cell biology experience, a strong publication record appropriate to career stage, excellent written and spoken English, and the ability to work independently and collaboratively in a multidisciplinary international environment. Desirable experience includes intestinal organoids, patient-derived material, fibroblast or immune-cell culture, epithelial–stromal–immune co-culture models, multimodal omics integration, advanced imaging, quantitative image analysis, flow cytometry, organoid phenotyping, high-content screening, CRISPR-engineered organoids, and intestinal organoid engraftment or transplantation. Interest in supervising junior researchers and contributing to teaching is also preferred.

How to apply

Apply electronically via the SDU application link and submit all requested PDFs in English. Include a motivation letter, CV, degree certificates including the PhD diploma, publication list, three selected peer-reviewed publications, teaching portfolio, detailed research experience, and other relevant qualifications. Applications must be complete and received by the deadline.

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