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Philipps-Universität Marburg

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Postdoctoral Research Assistant in GPCR Optical Biosensors and Developmental Cell Biology Philipps-Universität Marburg in Germany

Degree Level

Postdoc

Field of study

Cell Biology

Funding

Full-time, three-year position with salary and benefits according to the Hesse public service collective agreement, TV-H pay grade E 13. The position includes equal pay under the Hesse Collective Agreement and a ticket for free use of public transport throughout Hesse, Germany. Career development training and professional development opportunities, including training, coaching, and mentoring, are offered.

Deadline

Nov 22, 2026

Country flag

Country

Germany

University

Philipps-Universität Marburg

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Keywords

Cell Biology
Molecular Biology
Biomedical Engineering
Biology
Pharmacy
Bioinformatic
G Protein-coupled Receptor

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The Helker Lab at the University of Marburg is recruiting a Postdoctoral Researcher to investigate G protein-coupled receptor (GPCR) signaling and receptor dynamics. The project will focus on the development and validation of optical GPCR biosensors for studying how receptors respond to ligands and mechanical signals. The researcher will also contribute to GPCR mechanosensing studies, cell-based pharmacological assays, and structural modeling of GPCR–ligand interactions. The position is based in...

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About this position

Philipps-Universität Marburg is seeking a postdoctoral research assistant for the Department of Biology research group Developmental Genetics and Cell Biology of Animals, led by Professor Christian Helker.

The project focuses on the design, cloning, and application of optical biosensors for investigating the conformational dynamics of G protein-coupled receptors (GPCRs). The researcher will develop new biosensor fusion proteins and validate their performance in living cells, creating tools to measure receptor behavior in real time.

The work will examine how GPCRs respond to ligand binding and mechanical signals. It combines molecular biology, cell biology, pharmacology, and quantitative data analysis. The researcher will design and perform pharmacological and cell-biological assays in microtiter-plate formats, including assays with at least 96 wells, and will analyze and visualize large pharmacological datasets.

An additional component involves structural modeling of GPCR–ligand interactions, providing an opportunity to connect experimental biosensor development with molecular-level interpretation of receptor signaling. The position is embedded in a collaborative, innovative, and supportive research environment within a broad biology department.

The role offers opportunities for independent scientific work and further qualification as a postdoctoral researcher, supported by career development training, coaching, and mentoring.

Funding details

Full-time, three-year position with salary and benefits according to the Hesse public service collective agreement, TV-H pay grade E 13. The position includes equal pay under the Hesse Collective Agreement and a ticket for free use of public transport throughout Hesse, Germany. Career development training and professional development opportunities, including training, coaching, and mentoring, are offered.

What's required

Applicants must have an MSc degree or equivalent and a PhD in the life sciences, or provide evidence that doctoral studies are nearing completion. Extensive experience with molecular biology techniques for cloning new fusion proteins and with pharmacological assays in living cells using microtiter plates of at least 96 wells is required. Previous research experience involving GPCRs, G proteins, GRKs, or arrestins is required. Experience designing and validating new biosensors for use in living cells is desirable. Very good English skills are required.

How to apply

Apply online through the University of Marburg application button by 22 November 2026. Submit the required application materials through the online application portal.

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