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Imperial College London

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Postdoctoral Research Associate in Structural Biology of Bacterial Secretion Systems Imperial College London in United Kingdom

Degree Level

Postdoc

Field of study

Biochemistry

Funding

The position is funded by an 8-year Wellcome Trust Discovery award. Full-time fixed-term appointment for 24 months. Salary £50,733-£59,484 per annum; candidates without an officially awarded PhD may be appointed as Research Assistant at £45,399-£48,876 per annum. Visa costs associated with moving to the UK will be covered.

Deadline

Nov 16, 2026

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Country

United Kingdom

University

Imperial College London

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Keywords

Biochemistry
Chemistry
Biomedical Engineering
Biophysics
Biology
Structural Biology
Cryo-electron Microscopy
Protein Purification
Medical Science
Physics

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About this position

Research Associate on the structural biology of bacterial secretion systems at Imperial College London (South Kensington Campus, London, UK).

This is a postdoctoral research opening in the Department of Infectious Disease, working with Prof Harry Low and the Low Lab on the molecular mechanism of bacterial secretion systems, including the Tad and Type 4 pilus systems.

The project is strongly focused on structural biology, cryo-electron microscopy (SPA, in-situ SPA, tomography), TIRF microscopy, and single-molecule FRET, alongside protein purification, biochemical/biophysical analysis, and structure determination of challenging multi-component membrane complexes.

Funding: the role is supported by an 8-year Wellcome Trust Discovery award. The appointment is full-time, fixed-term for 24 months, with salary in the range £50,733–£59,484 per annum. If the PhD has not yet been officially awarded, the candidate may be appointed as a Research Assistant on £45,399–£48,876 per annum. Visa costs for moving to the UK will be covered.

Eligibility highlights: applicants should have a PhD in structural biology (cryo-EM, X-ray crystallography, or NMR), experience with protein structure-determination workflows from cloning/mutagenesis and purification through data collection, processing, and model building, and essential cryo-EM workflow experience. A strong publication record with at least one first-author paper in an international journal or bioRxiv is required; light microscopy experience is desirable.

How to apply: submit an application through the online portal using the Apply now link. Review the job description and apply before the closing date. The posting closes on 2026-11-16.

Funding details

The position is funded by an 8-year Wellcome Trust Discovery award. Full-time fixed-term appointment for 24 months. Salary £50,733-£59,484 per annum; candidates without an officially awarded PhD may be appointed as Research Assistant at £45,399-£48,876 per annum. Visa costs associated with moving to the UK will be covered.

What's required

PhD in structural biology is required, with training in cryo-EM, X-ray crystallography, or NMR. Experience designing and executing protein structure-determination workflows from molecular biology/biochemical experiments through data collection, processing, and model building is expected. Essential cryo-EM workflow experience includes sample preparation, data collection, and processing. Light microscopy experience is desirable. A strong research track record with at least one first-author publication in an international journal or bioRxiv is required. Candidates who have not yet been officially awarded their PhD may be appointed as a Research Assistant at a lower salary.

How to apply

Apply via the online application portal using the provided Apply now link. Review the job description and submit your application before the closing date. If you have technical issues, contact [email protected].

More information can be found here

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