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Montana State University

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Postdoctoral Researcher in Structural Biology and CRISPR-Cas Defense Systems Montana State University in United States

Degree Level

Postdoc

Field of study

Biochemistry

Funding

Postdoctoral Researcher position at Montana State University with salary commensurate with experience, education, and qualifications. Full-time, benefits eligible. The post notes that the position is not eligible for new sponsorship.

Deadline

Dec 31, 2026

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Country

United States

University

Montana State University

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Keywords

Biochemistry
Molecular Biology
Evolutionary Biology
Chemistry
Microbiology
Biomedical Engineering
Biology
Structural Biology
Cryo-electron Microscopy
Protein Purification
Bioinformatic
Physics

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About this position

Montana State University is recruiting a Postdoctoral Researcher in the Department of Microbiology & Cell Biology in Bozeman, Montana, United States.

The Wiedenheft Lab is seeking a highly motivated postdoc to study the structural mechanisms of bacterial immune systems that defend bacteria against viral (phage) infection. The project focuses on CRISPR-Cas complexes, Defense-associated Reverse Transcriptases (DRTs), Retrons, and other newly discovered anti-phage defense systems.

The position emphasizes structural biology with a strong cryo-EM component, especially single-particle cryo-electron microscopy. The successful candidate will determine high-resolution structures, prepare and characterize protein complexes, collect and process cryo-EM data using a 200 keV Thermo Fisher Talos Arctica, and integrate structural findings with biochemical, genetic, and evolutionary analyses.

Required background includes a Ph.D. in Structural Biology, Biochemistry, Biophysics, Microbiology, Molecular Biology, or a related field; hands-on cryo-EM experience; protein expression/purification expertise; troubleshooting ability; publication or preprint productivity; and strong communication and teamwork skills. Preferred experience includes Talos Arctica operation, membrane protein work, lipid nanodiscs, detergent-solubilized systems, computational phylogenetics, evolutionary genomics, and mentoring trainees.

This is a full-time, benefits-eligible research professional appointment with salary commensurate with experience, education, and qualifications. Applications are screened starting 2026-12-31 and will be accepted until an adequate applicant pool is established. The posting also notes that the position is not eligible for new sponsorship.

To apply, use the Montana State University jobs portal link provided in the post. Questions can be directed to Kelley Kane at [email protected].

Funding details

Postdoctoral Researcher position at Montana State University with salary commensurate with experience, education, and qualifications. Full-time, benefits eligible. The post notes that the position is not eligible for new sponsorship.

What's required

Ph.D. in Structural Biology, Biochemistry, Biophysics, Microbiology, Molecular Biology, or a related field. Hands-on experience with single-particle cryo-EM, including data collection, processing, and interpretation, is required. Applicants should have a strong background in protein expression, purification, and biochemical characterization, demonstrated troubleshooting and workflow optimization ability, evidence of productivity through publications or preprints, and excellent communication, teamwork, and organizational skills. Preferred experience includes cryo-EM at 200 keV or Talos Arctica operation, work on proteins involved in immunity, membrane protein purification, lipid nanodiscs or detergent-solubilized systems, computational phylogenetics or evolutionary genomics, and mentoring trainees.

How to apply

Apply through the Montana State University jobs portal using the View or Apply link. Screening begins on 2026-12-31, and applications will be accepted until an adequate applicant pool is established. Contact Kelley Kane by email for questions.

More information can be found here

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