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Nanyang Technological University
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Research Fellow in Infection Cell Biology and Expansion Microscopy Nanyang Technological University in Singapore
Degree Level
Postdoc
Field of study
Molecular Biology
Funding
Available
Country
Singapore
University
Nanyang Technological University
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About this position
Nanyang Technological University’s Lee Kong Chian School of Medicine is recruiting a Research Fellow for the Mesquita Lab in Singapore. The laboratory investigates how pathogens remodel host lipid membranes and how cells respond to infection-related damage, with particular emphasis on protein lipidation, or S-acylation, as a regulator of infection, immunity and organelle function.
The successful researcher will lead a project examining the spatial organisation of host and viral organelles during infection. A central goal is to establish expansion microscopy together with super-resolution imaging as a robust, quantitative capability for resolving host and viral membrane compartments. The work will explore how S-acylation influences membrane architecture, organelle contacts, compartment identity and viral replication compartments.
The project combines expansion microscopy, confocal and live-cell imaging, advanced fluorescence microscopy, quantitative image analysis, cell culture, molecular biology, genome editing, infection experiments and protein biochemistry. Complementary biochemical, biophysical and structural approaches may be incorporated as the research develops. The Research Fellow will also contribute to method development, interpretation of imaging datasets, scientific publications, presentations, grant applications and the mentoring of junior laboratory members.
As the Mesquita Lab is being established at LKCMedicine, the researcher will join at an early stage and help shape a collaborative research environment. The lab connects with researchers and core facilities across NTU and LKCMedicine, including imaging capabilities, as well as an international network of partners. The role supports the development of an independent research direction in infection, immunity, membrane biology and quantitative structural imaging.
Funding details
Available
What's required
Applicants must hold a PhD in cell biology, structural biology, biochemistry, biophysics, bioengineering, molecular biology, or a closely related discipline, with a strong research record including first-author publications in international peer-reviewed journals. Substantial hands-on experience in advanced fluorescence microscopy, including confocal and live-cell imaging, is required. Applicants should have practical experience with expansion microscopy or another super-resolution modality and interest in establishing expansion microscopy; experience imaging and structurally characterizing subcellular organelles or macromolecular assemblies; mammalian cell culture, molecular biology, protein biochemistry, and quantitative imaging-data analysis using software or scripting; and experience supervising or mentoring students. Excellent written and oral English communication, international presentation experience, independence in planning and delivering research, troubleshooting ability, teamwork, and motivation to develop an independent research direction and pursue external fellowship funding are required. Experience with protein production, X-ray crystallography, SAXS, cryo-EM, image-based screening, infection models, membrane biology, and subcellular structures is advantageous, with training available for some areas.
How to apply
Apply through the Nanyang Technological University Workday job portal using the provided Research Fellow vacancy link. Submit the requested application materials through the portal; only shortlisted candidates will be notified.
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