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Letellier

1 year ago

Stromal-epithelial crosstalk in colorectal cancer University of Luxembourg in Luxembourg

Degree Level

Postdoc

Field of study

Data Science

Funding

Yearly gross salary for every Postdoctoral Researcher at the University of Luxembourg is EUR 85,176 (full time).

Deadline

Sep 12, 2026

Country flag

Country

Luxembourg

University

University of Luxembourg

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Keywords

Data Science
Biostatistics
Biology
Computational Biology
Health Science
Single-cell Analysis
Colorectal Cancer
Immune Response
In Vivo Testing
Fibroblast Biology
Epithelial Biology
Organoid Technology
Multidrug Resistance
Tumor Progression
Bioinformatic
Spatial Transcriptomic

About this position

The University of Luxembourg is seeking a postdoctoral researcher to join a collaborative project investigating stromal-epithelial crosstalk in colorectal cancer (CRC) initiation, progression, and therapy resistance. The position is based within the Faculty of Science, Technology and Medicine (FSTM), which is known for its multidisciplinary expertise and international character. The successful candidate will work jointly between the University of Luxembourg and KU Leuven, under the guidance of Prof.

Letellier and Prof. Tejpar, in a highly collaborative and interdisciplinary environment. The research focuses on understanding how fibroblasts from healthy colon tissue transition into distinct cancer-associated fibroblast (CAF) subtypes and how these subtypes regulate epithelial plasticity and immune responses, thereby promoting tumor progression and therapy resistance.

The project leverages state-of-the-art single-cell RNA sequencing (scRNAseq), spatial transcriptomics, advanced co-culture organoid assays, and in vivo models to decode the mechanisms underlying CAF-driven CRC evolution. Access to clinical trial data through Prof. Tejpar's group provides a unique opportunity to study stromal interactions under novel treatments and explore their therapeutic potential. The postdoctoral fellow will apply innovative bioinformatics approaches to human-relevant models and patient-derived tissue cohorts, aiming to dissect the tumor ecosystem with a focus on epithelial cells, CAFs, and immune cells.

The role includes coordinating experiments, conducting bioinformatics analyses, ensuring scientific documentation, presenting data at consortium meetings and in publications, and contributing to general laboratory tasks. The position offers a fixed-term contract of 24 months, a competitive yearly gross salary of EUR 85,176, and support from a dedicated technician.

Applicants must have a PhD in a relevant discipline, strong computational and biostatistics skills, experience with single-cell sequencing and spatial omics, and a solid understanding of cancer biology. Applications should be submitted online, including a CV, cover letter, and contact details for at least two referees. The University of Luxembourg promotes an inclusive culture and encourages applications from all backgrounds.

Funding details

Yearly gross salary for every Postdoctoral Researcher at the University of Luxembourg is EUR 85,176 (full time).

What's required

Applicants must hold a PhD in Biological Sciences, Data Science, Computational Biology, or a related discipline. Prior professional experience as a Postdoctoral Researcher is preferred. Candidates should have a strong computational background with proficiency in R and at least one additional scripting language, solid knowledge of biostatistics, and experience with single-cell sequencing data (preferably spatial omics). Experience working in high-performance computing environments is highly preferred. A good understanding of cancer biology, immunology, cell biology, and molecular biology is required, along with a proven track record of peer-reviewed publications. Excellent spoken and written communication skills, strong organizational skills, and proficiency in written and spoken English are required.

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Professors

Professor at University of Luxembourg

University Name

University of Luxembourg

Research Interests

Biostatistics

Single-cell Analysis

Immune Response

Colorectal Cancer

In Vivo Testing

Professor at University of Luxembourg

University Name

University of Luxembourg

Research Interests

Biostatistics

In Vivo Testing

Single-cell Analysis

Biology

Fibroblast Biology