Adrian Krainer

Professor

Cold Spring Harbor Laboratory

United States

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Adrian Krainer is a Professor at Cold Spring Harbor Laboratory in the United States. His research primarily focuses on the therapeutic applications of antisense oligonucleotides, especially in the contexts of spinal muscular atrophy and pancreatic cancer. His recent publications explore various aspects of splicing mechanisms and their implications for disease treatment and drug targeting.

Articles (14)

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2025

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2022

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2022

Collaborators (4)

Charlotte Sumner

Professor

Johns Hopkins University

UNITED STATES

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John Wilkinson

Professor

University of Michigan

UNITED STATES

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Justin Kinney

Associate Professor

Cold Spring Harbor Laboratory

UNITED STATES

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Erika Tse-Luen Wee

Research Assistant Professor

Cold Spring Harbor Laboratory

UNITED STATES

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Adrian Krainer

Research Interests

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Articles (14)

Intra-amniotic antisense oligonucleotide treatment improves phenotypes in preclinical models of spinal muscular atrophy

Voltage-gated sodium channels in excitable cells as drug targets

SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23

Specificity, synergy, and mechanisms of splice-modifying drugs

Screening Splice-Switching Antisense Oligonucleotides in Pancreas-Cancer Organoids

Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer

Antisense oligonucleotide therapy for H3.3K27M diffuse midline glioma

Antisense Oligonucleotide Therapeutics for Cystic Fibrosis: Recent Developments and Perspectives

Higher-order epistasis and phenotypic prediction

Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy

Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy

ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth

Systematic characterization of short intronic splicing-regulatory elements in <i>SMN2</i> pre-mRNA

Exon-skipping antisense oligonucleotides for cystic fibrosis therapy

Collaborators (4)

Charlotte Sumner

John Wilkinson

Justin Kinney

Erika Tse-Luen Wee

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