Akihiro Sugawara

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Assistant professor

Tohoku University

Japan

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About

Dr. Akihiro Sugawara is an Assistant Professor at Tohoku University in Japan. His research focuses on the discovery and biosynthesis of natural products, with recent articles highlighting topics such as drug screening platforms using fission yeast and novel fungal secondary metabolites. His work also encompasses genome mining for natural product discovery and the synthetic adaptation of biosynthetically produced compounds. Dr. Sugawara's contributions advance the understanding of complex biochemical pathways in fungi and natural product chemistry.

Recent Grants

Grant: Close

クロストリジウム感染症治療薬を指向したマクロライドの全合成と抗菌力発現機構の解明

Open Date: 2016-04-01

Close Date:

Grant: Close

半田ビーズを利用した新規マクロライドの標的同定と天然物探索及び創薬リードの創製

Open Date: 2014-04-01

Close Date: 2016-03-01

Grant: Close

抗嫌気性菌活性を有する高歪み１０員環ラクトン天然物群の全合成と単純化天然物の創製

Open Date: 2014-04-01

Close Date: 2016-03-01

Grant: Close

半田ビーズを利用した新規マクロライドの抗炎症作用の作用機序解明と創薬リードの創製

Open Date: 2012-04-01

Close Date: 2014-03-01

Grant: Close

多置換オキサトリシクロウンデカン－マクロライド融合天然物の全合成と構造活性相関

Open Date: 2012-04-01

Close Date: 2014-03-01

Articles (14)

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JAPAN

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Yuzuru Kubohara

Professor

National Institute of Infectious Diseases

JAPAN

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Akihiro Sugawara

Research Interests

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About

Recent Grants

Articles (14)

Genome Mining-Based Discovery of Pyrano[2,3-<i>c</i>]pyrrole Type Natural Products Possessing Alkyl Side Chain with Branched Methyl Groups

Ketosynthase Domain Catalyzes β-Lactonization in the Biosynthesis of the HMG-CoA Synthase Inhibitor Hymeglusin

Biosynthesis of Circumdatins Employs an Anthranilate Tailoring Pathway for NRPS Substrate Supplies

Discovery and Theoretical Studies of Nonenzymatic Polyketide Dimerizations of Chaetophenols

Construction of a New Drug and Agrochemical Candidates Screening Platform Utilizing Drug-Hypersensitive Fission Yeast to Discover Overlooked Natural Products

New benzoyl sesquiterpenoid, aoganolide, produced by Talaromyces sp. KTF-0021 strain (laeA-introduced mutant of FKI-5759 strain)

Novel Tetrapeptides, Tengupeptins A and B, Produced by Lecanicillium aphanocladii FKI‐9593 Fungal Strain

laeA Gene Introduction Strategy Enabling the Construction of a Prolific Fungal Secondary Metabolite Library

Genome mining of labdane-related diterpenoids: Discovery of the two-enzyme pathway leading to (−)-sandaracopimaradiene in the fungus Arthrinium sacchari

Semi-synthesis of a DNA-Tagged Polyketide–Peptide Hybrid Macrocycle Using a Biosynthetically Prepared Fungal Macrolide as a Synthetic Component

Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase

Discovery of a Cyclic Depsipeptide from <i>Chaetomium mollipilium</i> by the Genome Mining Approach

Pd-catalyzed Regio- and Stereoselective Hydrostannylation of an Alkyl Ethynyl Ether/One-Pot Stille Coupling Enables the Synthesis of 14-Membered Macrolactone of Luminamicin

Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds

Collaborators (12)

Taro Ozaki

Yohei Morishita

Takeshi Yamada

Yuki Inahashi

Aoi Kimishima

Yuzuru Kubohara

Haruhisa Kikuchi

Yoshihiro Watanabe

Teigo Asai

Tatsuya Ikuta

Shigehiro Kawashima

Masato Suzuki

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