Akiyuki Nishimura

特任准教授/Project Associate Professor

生理学研究所/National Institute for Physiological Sciences

Japan

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Akiyuki Nishimura is a Project Associate Professor at the National Institute for Physiological Sciences, Japan. His research focuses on cardiovascular physiology, particularly in the mechanisms of vascular smooth muscle cells, purinergic signaling, and sulfur metabolism as potential therapeutic targets for heart failure. Recent publications include studies on TRPC6-mediated Zn 2+ influx, the impact of the P2Y 6 receptor, and novel compounds in cardiac health and disease.

Articles (13)

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2025

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2025

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2025

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2024

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2024

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2024

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2024

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2023

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2023

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2022

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JAPAN

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Tomoya Ito

Assistant Professor

Kyushu University

JAPAN

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Takuya Kuroda

Chief

National Institute of Health Sciences

JAPAN

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Professor

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Akiyuki Nishimura

Research Interests

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Articles (13)

TRPC6-Mediated Zn<sup>2+</sup> Influx Negatively Regulates Contractile Differentiation of Vascular Smooth Muscle Cells

Ligand-Independent Spontaneous Activation of Purinergic P2Y6 Receptor Under Cell Culture Soft Substrate

Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice

2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels

Sulfur metabolism as a new therapeutic target of heart failure

Inhibition of Drp1–Filamin Protein Complex Prevents Hepatic Lipid Droplet Accumulation by Increasing Mitochondria–Lipid Droplet Contact

Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression

Diabetic Mice Spleen Vulnerability Contributes to Decreased Persistence of Antibody Production after SARS-CoV-2 Vaccine

Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis

Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice

Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression

Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors

Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity

Collaborators (12)

Takuro Numaga-Tomita

Hiroshi Tanaka

Xinya Mi

Tomohiro Tanaka

Motohiro Nishida

Kazuhiro Nishiyama

Tomoya Ito

Takuya Kuroda

Takahiro Shibata

Meg Shieh

Yara Atef Ahmed

Gentaro Iribe

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