Alain Gobert

Research Professor of Medicine

Vanderbilt University Medical Center

United States

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Alain Gobert is a Research Professor of Medicine at Vanderbilt University Medical Center in the United States. His research focuses on colorectal carcinogenesis, the role of polyamines in gastric inflammation, and the impact of epithelial cell functions on intestinal health. Recent publications highlight his work on hypusination processes and their implications in various gastrointestinal diseases, including infections and cancer.

Articles (17)

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2025

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2020

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2020

Collaborators (4)

Lori Coburn

Associate Professor

Vanderbilt University Medical Center

UNITED STATES

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Jeremy Goettel

Assistant Professor

Vanderbilt University Medical Center

UNITED STATES

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Gregory Jubelin

Université Clermont Auvergne

FRANCE

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Keith T. Wilson

Vanderbilt University Medical Center

UNITED STATES

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Alain Gobert

Research Interests

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Articles (17)

Protective role of epithelial deoxyhypusine synthase in colorectal carcinogenesis caused by deletion of the adenomatous polyposis coli gene

Alterations in polyamine metabolism induced by the pathogen Helicobacter pylori: Implications for gastric inflammation and carcinogenesis.

Hypusination in intestinal epithelial cells protects mice from infectious colitis

Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production.

Analysis of the effect of hypusination in myeloid cells on colitis and colitis-associated cancer

Analysis of the effect of hypusination in myeloid cells on colitis and colitis-associated cancer

Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease

The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice

Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification

The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori

Epithelial talin-1 protects mice from <i>Citrobacter rodentium</i> -induced colitis by restricting bacterial crypt intrusion and enhancing T cell immunity

Electrophilic reactive aldehydes as a therapeutic target in colorectal cancer prevention and treatment

Induction and Regulation of the Innate Immune Response in Helicobacter pylori Infection

Protective Role of Spermidine in Colitis and Colon Carcinogenesis.

Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis

Hypusination Orchestrates the Antimicrobial Response of Macrophages

Interplay between enterohaemorrhagic Escherichia coli and nitric oxide during the infectious process

Collaborators (4)

Lori Coburn

Jeremy Goettel

Gregory Jubelin

Keith T. Wilson

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