Alec Simon Tulloch Smith

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Research Assistant Professor

University of Washington

United States

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About

Alec Simon Tulloch Smith is a Research Assistant Professor at the University of Washington in the United States. His research focuses on engineered neuromuscular tissues, neurotoxin potency testing, heart-on-a-chip platforms, and the pathological mechanisms of ALS. He is particularly interested in developing innovative assays for detecting amyloidogenic toxic oligomers and studying the effects of mutations associated with Charcot-Marie-Tooth disease.

Recent Grants

Grant: Close

Using functional readouts from engineering models of innervated skeletal muscle to assess the efficacy of CRISPR-based c9orf72 ALS gene therapies

Open Date: 2022-07-01

Close Date: 2024-06-30

Grant: Close

High-throughput nanoMEA-based Proarrhythmia Assay

Open Date: 2016-09-01

Close Date: 2017-08-31

Articles (14)

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2025

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2024

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2024

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2024

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2020

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2020

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2020

Collaborators (4)

Christopher Keene

Associate Professor

University of Washington

UNITED STATES

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Lisa Maves

Seattle Children's Research Institute

UNITED STATES

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Paul Valdmanis

Associate Professor

University of Washington

UNITED STATES

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Alessandro Bertero

ITALY

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Alec Simon Tulloch Smith

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (14)

An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing.

Spaceflight-induced contractile and mitochondrial dysfunction in an automated heart-on-a-chip platform

Human Motor Neurons Elicit Pathological Hallmarks of ALS and Reveal Potential Biomarkers of the Disease in Response to Prolonged IFNγ Exposure.

Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers

High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing.

Conformational sampling of CMT-2D associated GlyRS mutations

HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D).

Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies.

Tunable electroconductive decellularized extracellular matrix hydrogels for engineering human cardiac microphysiological systems.

Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro.

A More Open Approach Is Needed to Develop Cell-Based Fish Technology: It Starts with Zebrafish

Nanopatterned Nafion microelectrode arrays for in vitro cardiac electrophysiology.

Engineering anisotropic 3D tubular tissues with flexible thermoresponsive nanofabricated substrates.

Collaborators (4)

Christopher Keene

Lisa Maves

Paul Valdmanis

Alessandro Bertero

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