Alemahehu A. Gorfe

Professor

The University of Texas Health Science Center at Houston

United States

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Dr. Alemahehu A. Gorfe is a Professor at The University of Texas Health Science Center at Houston, USA. His research focuses on the biophysics of small GTPases, lipid interactions, and membrane dynamics, as evidenced by his recent publications. Notable articles include studies on RAS–membrane interactions, the regulation of GTPase function by intrinsically disordered regions, and the exploration of KRAS inhibition through small molecules.

Articles (16)

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2025

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2024

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2024

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2024

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2024

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2023

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2020

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2020

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2020

Collaborators (4)

YUBIN ZHOU

Professor, Presidential Impact Fellow & Program Leader

Texas A&M University

UNITED STATES

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sharon campbell

Liebscher Distinguished Professor

University of North Carolina at Chapel Hill

UNITED STATES

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Krishna Mohan Sepuru

Howard Hughes Medical Institute

UNITED STATES

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Junchen Liu

Assistant Professor

The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical School

UNITED STATES

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Alemahehu A. Gorfe

Research Interests

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Articles (16)

RAS–membrane interaction and oligomerization: there is more than meets the eye

From disorder comes function: Regulation of small GTPase function by intrinsically disordered lipidated membrane anchor

Differential Lipid Binding Specificities of RAP1A and RAP1B are Encoded by the Amino Acid Sequence of the Membrane Anchors

Intrinsically Disordered Membrane Anchors of Rheb, RhoA, and DiRas3 Small GTPases: Molecular Dynamics, Membrane Organization, and Interactions

Biophysical and Biochemical Characterization of Structurally Diverse Small Molecule Hits for KRAS Inhibition

Small-Molecule Inhibition of KRAS through Conformational Selection

Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases

Biophysics of cancer

Phosphatidylserine and Phosphatidylethanolamine Asymmetry Have a Negligible Effect on the Global Structure, Dynamics, and Interactions of the KRAS Lipid Anchor

Determinants of Membrane Orientation Dynamics in Lipid-Modified Small GTPases

Building insights into KRAS signaling complexes

Monoubiquitination of KRAS at Lysine104 and Lysine147 Modulates Its Dynamics and Interaction with Partner Proteins

The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure

Long-Range Coupled Motions Underlie Ligand Recognition by a Chemokine Receptor

Mechanisms of Ras Membrane Organization and Signaling: Ras Rocks Again

Transmembrane potential of physiologically relevant model membranes: Effects of membrane asymmetry

Collaborators (4)

YUBIN ZHOU

sharon campbell

Krishna Mohan Sepuru

Junchen Liu

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