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Alessio Branchini

Senior Assistant Professor of Molecular Biology

University of Ferrara

Italy

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Research Interests

Biochemistry

40%

Pharmacology

40%

Hemostasis

60%

Proteostasis

40%

Pharmacogenomic

30%

Hemophilia

30%

Protein Synthesis

20%

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Recent Grants

Grant: Close

Novo Nordisk Access to Insight Basic Research Grant 2021 - Insights into the contribution of tailored collagen binding to half-life of designed factor IX fusion proteins

Open Date: 2021-09-01

Close Date: 2023-09-01

Grant: Close

Bayer Early Career Investigator Award - Factor IX variants with superior pharmacokinetics as next-generation therapeutics for Haemophilia B

Open Date: 2018-09-01

Close Date: 2020-06-01

Grant: Close

Grifols Martin Villar Haemostasis Award - Do residual FVIII levels associated with F8 nonsense mutations reduce the inhibitor risk in hemophilia A patients?

Open Date: 2018-09-01

Close Date: 2020-09-01

Grant: Close

Pfizer EUROPE ASPIRE 2015 Grant - Improved intracellular processing of protein variants as a personalized therapeutic approach for Haemophilia

Open Date: 2015-09-01

Close Date: 2017-06-01

Alessio Branchini

Senior Assistant Professor of Molecular Biology

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Research Interests

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Recent Grants

Articles16

“An integrated multitool analysis contributes elements to interpreting unclassified factor IX missense variants associated with hemophilia B”: reply

Nonsense Mutations in Rare and Ultra‐Rare Human Disorders: An Overview

Advancing Therapeutic Strategies for Nonsense‐Related Diseases: From Small Molecules to Nucleic Acid‐Based Innovations

Platelet transcriptomic changes in myocardial infarction are sex and clinical subtype-related: a step forward towards precision medicine?

Engineered tRNAs efficiently suppress CDKL5 premature termination codons

An integrated multitool analysis contributes elements to interpreting unclassified factor IX missense variants associated with hemophilia B

1,3,8-Triazaspiro[4.5]decane Derivatives Inhibit Permeability Transition Pores through a FO-ATP Synthase c Subunit Glu119-Independent Mechanism That Prevents Oligomycin A-Related Side Effects

Modulation of factor VIII pharmacokinetics by genetic components in factor VIII receptors

F9 missense mutations impairing factor IX activation are associated with pleiotropic plasma phenotypes

The p.P1127S pathogenic variant lowers von Willebrand factor levels through higher affinity for the macrophagic scavenger receptor LRP1: Clinical phenotype and pathogenic mechanisms

The Asialoglycoprotein Receptor Minor Subunit Gene Contributes to Pharmacokinetics of Factor VIII Concentrates in Hemophilia A

Fusion of engineered albumin with factor IX Padua extends half‐life and improves coagulant activity

The Factor VII Variant p.A354V-p.P464Hfs: Clinical versus Intracellular and Biochemical Phenotypes Induced by Chemical Chaperones

The carboxyl‐terminal region of coagulation serine proteases: A matter of cut and change

Molecular Insights into Determinants of Translational Readthrough and Implications for Nonsense Suppression Approaches

An Exon-Specific Small Nuclear U1 RNA (ExSpeU1) Improves Hepatic OTC Expression in a Splicing-Defective spf/ash Mouse Model of Ornithine Transcarbamylase Deficiency

Collaborators12

Dario Balestra

Mariasanta Napolitano

Donato Gemmati

Mirko Pinotti

Nicola Martinelli

Silvia Lombardi

Claudio Trapella

Gianluca Campo

Carlotta Giorgi

Jan Terje Andersen

Stan F.J. van de Graaf

Paola Giordano

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