Alex Holehouse

Assistant Professor

Washington University in Saint Louis School of Medicine

United States

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Articles (17)

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2024

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2022

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2022

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2022

Collaborators (11)

Clay Wright

Assistant Professor

Virginia Polytechnic Institute and State University

UNITED STATES

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Shahar Sukenik

University of California

UNITED STATES

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Liam Holt

Associate Professor

New York University Grossman School of Medicine

UNITED STATES

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Garrett Ginell

Washington University in St. Louis

UNITED STATES

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Andrea Soranno

Assistant Professor

Washington University in St. Louis

UNITED STATES

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Brian Bothner

Professor

Montana State University

UNITED STATES

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Rohit Pappu

Gene K. Beare Distinguished Professor

Washington University in St. Louis

UNITED STATES

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Qionghua Shen

University of Texas Southwestern Medical Center

UNITED STATES

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Xiaolu Yang

Duke University

UNITED STATES

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Hongwei Jing

Washington University in St. Louis

UNITED STATES

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Jeffrey Lotthammer

Ohio State University

UNITED STATES

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Alex Holehouse

Research Interests

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Articles (17)

The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA

Direct prediction of intrinsically disordered protein conformational properties from sequence

Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation

Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator

Phase transition of GvpU regulates gas vesicle clustering in bacteria

The molecular basis for cellular function of intrinsically disordered protein regions

Intrinsically disordered regions are poised to act as sensors of cellular chemistry

Nitric oxide-mediated S-nitrosylation of IAA17 protein in intrinsically disordered region represses auxin signaling

The Analytical Flory Random Coil Is a Simple-to-Use Reference Model for Unfolded and Disordered Proteins

SOURSOP: A Python Package for the Analysis of Simulations of Intrinsically Disordered Proteins

SHEPHARD: a modular and extensible software architecture for analyzing and annotating large protein datasets

A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy.

Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates.

Stress granules offer first aid for leaky organelles

Hyperphosphorylation tunes TDP-43 solubility

SWI/SNF senses carbon starvation with a pH-sensitive low-complexity sequence

Intrinsically disordered CO2 sensors

Collaborators (11)

Clay Wright

Shahar Sukenik

Liam Holt

Garrett Ginell

Andrea Soranno

Brian Bothner

Rohit Pappu

Qionghua Shen

Xiaolu Yang

Hongwei Jing

Jeffrey Lotthammer

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