Alexander Bick

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Assistant Professor

Vanderbilt University

United States

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About

Alexander Bick is an Assistant Professor at Vanderbilt University in the United States. His research focuses on clonal hematopoiesis and its implications for metabolic disease, cardiovascular events, and hypertension. Recent publications highlight the role of various genetic mutations in hematopoiesis and inflammation associated with chronic conditions. Bick's work aims to elucidate the complex interactions between genetic factors and health outcomes in diverse populations.

Recent Grants

Grant: Close

Targeting Clonal Hematopoiesis of Indeterminate Potential using Human Genetics

Open Date: 2020-09-15

Close Date: 2025-08-31

Grant: Close

Targeting clonal hematopoiesis using human genetics

Open Date: 2020-09-01

Close Date: 2025-08-31

Articles (23)

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2022

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2022

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2022

Collaborators (18)

Michael Rauh

Associate Professor and Attending Hematopathologist

CANADA

Alexander Bick

Research Interests

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About

Recent Grants

Articles (23)

Interleukin-17 receptor-A signalling: atheroprotective role in JAK2 clonal haematopoiesis

Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice

Association of Clonal Hematopoiesis of Indeterminate Potential with Cardiovascular Events in Patients with CKD

Solid Organ Transplant Recipients Exhibit More TET2-Mutant Clonal Hematopoiesis of Indeterminate Potential Not Driven by Increased Transplantation Risk

Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis

Genetic determinants and phenotypic consequences of blood T-cell proportions in 207,000 diverse individuals

VEXAS‐Defining UBA1 Somatic Variants in 245,368 Diverse Individuals in the NIH All Of Us Cohort

Genomic data in the All of Us Research Program

JAK2-mutant Clonal Hematopoiesis is Associated with Venous Thromboembolism

Salt and CHIP: Tet2 -CH Aggravates Salt-Sensitive Hypertension in Mice

Genetic determinants and phenotypic consequences of blood T-cell proportions in 207,000 diverse individuals

<i>SRCAP</i> mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation (vol 30, pg 1503, 2023)

Acquired blood mutations cause acute kidney injury via dysregulated inflammation

Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood

Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment.

Infection risk associated with clonal hematopoiesis of indeterminate potential is partly mediated by hematologic cancer transformation in the UK Biobank

Clonal Hematopoiesis in Young Women Treated for Breast Cancer

Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis

Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank

Development and validation of the Vanderbilt PRS-KS, an instrument to quantify polygenic risk score knowledge

Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

Genetic determinants of interleukin-6 levels and risk of end-stage renal disease

Genetic causes and cardiovascular consequences of clonal hematopoiesis in the UK Biobank

Collaborators (18)

Michael Rauh

Shriie Ganesh

Katharine Clapham

Zsu-Zsu Chen

Benjamin Ebert

Ashwin Kishtagari

Michael Savona

Ran Tao

TONG XIAO

Zhi Yu

Robert Gerszten

Lee Wheless

Josh Denny

Jason Springer

Abhishek Niroula

Cheng-Chieh Hsu

Yaomin Xu

Yang Pan

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