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Alexander Birbrair

Tenure-track Assistant Professor

University of Wisconsin-Madison

United States

Research Interests

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About

Dr. Alexander Birbrair is a Tenure-track Assistant Professor at the University of Wisconsin–Madison, USA. His research focuses on the molecular mechanisms underlying cancer resistance, neuroinflammation, and innovative therapeutic approaches for infectious and inflammatory diseases. Recent publications highlight his work on antibody-drug conjugate resistance in breast cancer, neuroprotective effects of caffeine, and advancements in dengue vaccination strategies.

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Collaborators (7)

Enrrico Bloise

Associate Professor

University of Toronto

CANADA

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Shoichiro Takeishi

Associate/Staff Scientist

Albert Einstein College of Medicine

UNITED STATES

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Aaron James

Johns Hopkins University

UNITED STATES

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Debpali Sur

Scientist 1

University of Wisconsin-Madison

UNITED STATES

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David Simon

Assistant Professor

Weill Cornell Medical College

UNITED STATES

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Benjamin Levi

University of Texas Southwestern

UNITED STATES

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Deepak Sahasrabudhe

Professor of Medicine and oncology

University of Rochester Medical Center

UNITED STATES

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Alexander Birbrair

Research Interests

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About

Articles (29)

Circulating Tumor DNA (ctDNA) Clearance After Immune Checkpoint Inhibition (ICI) with Radiotherapy (RT) as a Prognostic Biomarker for Advanced Melanoma

β2-Adrenergic receptor disruption exacerbates cardiac injury and fibroblast activation in a female mouse model of Takotsubo cardiomyopathy

Tissue‐Level Transcriptomic Entropy Reveals Organ‐Specific Aging Patterns and Predicts Cancer Progression

Impact of antibiotics on survival outcomes and risk of gastritis/colitis in advanced-stage melanoma patients receiving immune checkpoint inhibitor therapy.

Sensitivity of Circulating Tumor DNA for Detection of Minimal Residual Disease Recurrence or Relapse in Patients With Melanoma

Alternative splicing generates HER2 isoform diversity underlying antibody–drug conjugate resistance in breast cancer

Activation of the β2-adrenoceptor by formoterol induces calcium-dependent exocytosis of synaptic vesicles at the neuromuscular junction in a sex-specific manner

Erratum: Entangled cellular and molecular relationships at the sensory neuron-cancer interface (Neuron (2025) 113(17) (2760–2790), (S0896627325005240), (10.1016/j.neuron.2025.07.017))

Next-gen tools in cancer neuroscience

Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury.

Single-cell sequencing uncovers sensory neuron-mediated CGRP signaling as a driver of sarcoma progression.

Cisplatin treatment induces a shift toward a quiescent Ki-67⁻/CD44⁺/CD133⁺ cancer stem cell subpopulation in a tumorsphere model derived from a murine non-small cell lung cancer cell line.

Genetic polymorphisms in the E2 glycoprotein of chikungunya virus (2014-2023) and their potential implications for immunity and vaccine design.

Beyond the Amazon: vector surveillance and emerging Oropouche virus in South America.

ctDNA Dynamics Identifies Pseudoprogression in a Metastatic Melanoma Patient Treated With Nivolumab/Relatlimab.

Malignant Melanoma With Transdifferentiation Into a Ganglioneuroblastic Phenotype After Anti-PD-1 Therapy.

Microfluidic Characterization and Analysis of Circulating Tumor Cells From Patients With Metastatic Melanoma.

Andrographolide increases adult hippocampal neurogenesis and prolongs contextual fear memory.

Successful use of nivolumab and relatlimab as salvage therapy for metastatic uveal melanoma.

Photobiomodulation therapy induces NG2 activation through dermal adipocyte lipolysis during wound healing.

Adora2A downregulation promotes caffeine neuroprotective effect against LPS-induced neuroinflammation in the hippocampus

Advancing dengue vaccination using a T-cell priming peptide approach

Pericytes as the Orchestrators of Vasculature and Adipogenesis

Pericytes as the Orchestrators of Vasculature and Adipogenesis

<i>Lactococcus lactis</i> as an Interleukin Delivery System for Prophylaxis and Treatment of Inflammatory and Autoimmune Diseases

Impact of social distancing from the COVID-19 pandemic on the immuno-inflammatory response of older adults

Nanoparticle-based DNA vaccine protects against SARS-CoV-2 variants in female preclinical models

New Perspectives in Stem Cell Transplantation and Associated Therapies to Treat Retinal Diseases: From Gene Editing to 3D Bioprinting

Novel Proline Transporter Inhibitor (LQFM215) Presents Antipsychotic Effect in Ketamine Model of Schizophrenia

Collaborators (7)

Enrrico Bloise

Shoichiro Takeishi

Aaron James

Debpali Sur

David Simon

Benjamin Levi

Deepak Sahasrabudhe

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