Alexander Gottschalk

Full Professor

Goethe University Frankfurt

Germany

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Alexander Gottschalk is a Full Professor at Goethe-Universität Frankfurt am Main, Germany. His research primarily focuses on neurobiology, with recent articles exploring neuronal activity regulation, synaptic transmission, and the effects of channelrhodopsins in Caenorhabditis elegans. He has a keen interest in the mechanisms of neuropeptidergic regulation and its implications for neuromuscular signaling and behavior in various model organisms.

Articles (20)

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2025

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2020

Collaborators (11)

Matthew Nelson

Associate Professor

Saint Joseph's University

UNITED STATES

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Peter Soba

Professor

Friedrich-Alexander Universität Erlangen-Nürnberg

GERMANY

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Zacharias Kontarakis

Head of GEML

Eidgenössische Technische Hochschule Zürich

SWITZERLAND

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Shunji Nakano

Nagoya University

JAPAN

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Ann M Wehman

Assistant Professor

University of Denver

UNITED STATES

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Franziska Schneider-Warme

University Medical Center Freiburg

GERMANY

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Cornelia Bargmann

Professor and Head of Laboratory

Rockefeller University

UNITED STATES

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Shigeki Watanabe

Associate Professor

Johns Hopkins University School of Medicine

UNITED STATES

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Olivier Mirabeau

Institut Pasteur

FRANCE

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Isabel Beets

Research Tenure Track Professor

KU Leuven

BELGIUM

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J. Simon Wiegert

University Medical Center Hamburg-Eppendorf

GERMANY

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Alexander Gottschalk

Research Interests

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Articles (20)

Potassium-selective channelrhodopsins can exert hyper- or depolarizing effects in excitable cells of Caenorhabditis elegans, depending on experimental conditions

Neurons and molecules involved in noxious light sensation in Caenorhabditis elegans

Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+ ATPase to promote recycling of synaptic vesicles

Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+ ATPase to promote recycling of synaptic vesicles

Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength

Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission

Tools and methods for cell ablation and cell inhibition in Caenorhabditis elegans

RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits

Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair

All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals.

pOpsicle: An all-optical reporter system for synaptic vesicle recycling combining pH-sensitive fluorescent proteins with optogenetic manipulation of neuronal activity.

Structure-function analysis suggests that the photoreceptor LITE-1 is a light-activated ion channel

Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles

Optogenetic tools for manipulation of cyclic nucleotides functionally coupled to cyclic nucleotide‐gated channels

BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons.

Synapsin is required for dense core vesicle capture and cAMP-dependent neuropeptide release

Context-dependent operation of neural circuits underlies a navigation behavior in Caenorhabditis elegans

Transcriptional adaptation in Caenorhabditis elegans

RPamide neuropeptides NLP-22 and NLP-2 act through GnRH-like receptors to promote sleep and wakefulness in C. elegans.

Optogenetic analyses of neuronal networks that generate behavior in Caenorhabditis elegans

Collaborators (11)

Matthew Nelson

Peter Soba

Zacharias Kontarakis

Shunji Nakano

Ann M Wehman

Franziska Schneider-Warme

Cornelia Bargmann

Shigeki Watanabe

Olivier Mirabeau

Isabel Beets

J. Simon Wiegert

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