Alexander I. Taylor

University of Cambridge

United Kingdom

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Articles (8)

Year:

2023

Blends of engineered polymerases enable efficient DNA-templated synthesis and reverse transcription of diverse-sequence oligonucleotide libraries composed of locked nucleic acid (LNA), 2′- O -methyl-RNA (2′OMe-RNA), or mixtures of the two.

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2020

Collaborators (1)

Amy Whitaker

Assistant Professor

Fox Chase Cancer Center

UNITED STATES

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Alexander I. Taylor

Research Interests

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Articles (8)

Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif

Efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues

A two-residue nascent-strand steric gate controls synthesis of 2'-O-methyl- and 2'-O-(2-methoxyethyl)-RNA.

A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing

On gene silencing by the X10-23 DNAzyme

Targeting non-coding RNA family members with artificial endonuclease XNAzymes

XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection

Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity

Collaborators (1)

Amy Whitaker

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