Alexandre Orthwein

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Assistant Professor

Emory University School of Medicine

United States

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Dr. Alexandre Orthwein is an Assistant Professor at Emory University School of Medicine in the United States. His research areas include DNA double-strand break repair, the regulation of bioenergetic homeostasis in acute myeloid leukemia, and the role of ADP-ribosylation in cellular processes. He has published extensively on topics ranging from gene editing techniques to novel therapeutic targets in cancer treatment.

Recent Grants

Grant: Close

Genome Stability and Haematological Malignancies

Open Date: 2016-10-01

Close Date: 2021-10-01

Articles (11)

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2024

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2023

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2022

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2022

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2022

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2022

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2021

Collaborators (5)

Sonia del Rincon

Associate Professor

McGill University Faculty of Medicine

CANADA

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Alexandre Maréchal

Professor

Université de Sherbrooke

CANADA

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Wilson H Miller Jr

McGill University

CANADA

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Remya Nair

Emory University

UNITED STATES

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Lidia Feliubadaló

SPAIN

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Alexandre Orthwein

Research Interests

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About

Recent Grants

Articles (11)

An E3 ubiquitin ligase localization screen uncovers DTX2 as a novel ADP-ribosylation-dependent regulator of DNA double-strand break repair

The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma.

B cell-specific knockout of AID protects against atherosclerosis.

A decade of RAD51C and RAD51D germline variants in cancer

EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax.

Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability.

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies.

Multi-omics data integration analysis identifies the spliceosome as a key regulator of DNA double-strand break repair.

POGZ promotes homology-directed DNA repair in an HP1-dependent manner

Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance

Common clonal origin of chronic myelomonocytic leukemia and B-cell acute lymphoblastic leukemia in a patient with a germline CHEK2 variant

Collaborators (5)

Sonia del Rincon

Alexandre Maréchal

Wilson H Miller Jr

Remya Nair

Lidia Feliubadaló

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