Alicia A. McDonough

We used a computational model of the renal tubule to assess the impact of 2-wk angiotensin II (ANG II) infusion on the handling of Na + and K + in female rats. ANG II strongly stimulates distal Na + reabsorption and K + secretion. Simulations indicate that substantial downregulation of proximal tubule NHE3 is needed to reestablish Na + balance at 2 wk. Proximal adaptations challenge K + homeostasis, and regulation of distal NCC and specific K + channels likely limit urinary K + losses.