Amala Soumyanath

Associate Professor

Oregon Health & Science University

United States

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Amala Soumyanath is an Associate Professor at Oregon Health and Science University in the United States. Her research focuses on the pharmacological effects of botanical supplements, particularly Centella asiatica, exploring its impact on cognitive function, antioxidant pathways, and DNA methylation changes. Recent articles highlight her work on mass spectrometry techniques and bioactive compound quantification related to mental health and neurodegenerative diseases.

Articles (17)

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2025

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2021

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2020

Assistant Professor

Oregon State University

UNITED STATES

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Amala Soumyanath

Research Interests

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Articles (17)

Development of a Proton Spin Network Fingerprint Library to Support Mass Spectrometry-Based Identification of Pharmacophore-Bearing Constituents in the Botanical Supplement Centella asiatica

Oral Asiatic Acid Improves Cognitive Function and Modulates Antioxidant and Mitochondrial Pathways in Female 5xFAD Mice

Peripheral Blood DNA Methylation Changes in Response to Centella asiatica Treatment in Aged Mice

Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of <i>C. asiatica</i> Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity

<i>Centella asiatica</i> Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis

Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of Centella asiatica

Quantifying Withanolides in Plasma: Pharmacokinetic Studies and Analytical Methods

Withania somnifera (Ashwagandha) Improves Spatial Memory, Anxiety and Depressive-like Behavior in the 5xFAD Mouse Model of Alzheimer’s Disease

Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice

Quantification of caffeoylquinic acids and triterpenes as targeted bioactive compounds of Centella Asiatica in extracts and formulations by liquid chromatography mass spectrometry

Chlorogenic Acids, Acting via Calcineurin, Are the Main Compounds in Centella asiatica Extracts That Mediate Resilience to Chronic Stress in Drosophila melanogaster

Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized <i>Centella asiatica</i> Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial

Withania somnifera Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in Drosophila melanogaster; a Possible Role of Other Compounds besides Withanolides

Withania somnifera and Centella asiatica Extracts Ameliorate Behavioral Deficits in an In Vivo Drosophila melanogaster Model of Oxidative Stress

Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging

Centella asiatica Water Extract Shows Low Potential for Cytochrome P450–Mediated Drug Interactions

Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice

Collaborators (8)

Alexander Law

Jan F. Stevens

Jacob Raber

Joseph Quinn

Claudia S. Maier

Yuan Jiang

L. Harinantenaina Rakotondraibe

Kevin Brown

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