Amanda Unsworth

Senior Lecturer

Manchester Metropolitan University

United Kingdom

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Dr. Amanda Unsworth is a Senior Lecturer at Manchester Metropolitan University, UK. Her research focuses on platelet activation and thromboinflammatory responses, as evidenced in her recent articles addressing metabolic reprogramming, reactive oxygen species, and various cellular mechanisms involved in vascular health and disease. Her work also explores the role of biomarkers in conditions like cancer-associated venous thrombosis and the implications for atherothrombosis.

Articles (20)

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2025

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2021

Collaborators (16)

Stephen White

Reader in Cardiovascular Biology

Newcastle University

UNITED KINGDOM

Amanda Unsworth

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Articles (20)

TRIPLE Score: GPVI and CD36 Expression Predict a Prothrombotic Platelet Function Phenotype

Metabolic Reprogramming in Toll-like Receptor-Mediated Platelet Activation

Platelet Reactive Oxygen Species, Oxidised Lipid Stress, Current Perspectives, and an Update on Future Directions

Vascular Endothelial Growth Factor (VEGF) as a Biomarker for Cancer-Associated Venous Thrombosis: A Meta-analysis

Constitutive surface expression of the thromboxane A2 receptor is Pim kinase-dependent

The Role of the VWF/ADAMTS13 Axis in the Thromboinflammatory Response in Ischemic Stroke After SARS-CoV2 Infection

Pim Kinase Inhibition Disrupts CXCR4 Signalling in Megakaryocytes and Platelets by Reducing Receptor Availability at the Surface

Differential Proteoglycan Expression in Atherosclerosis Alters Platelet Adhesion and Activation

Delineating Zinc Influx Mechanisms during Platelet Activation

The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications

The rate of platelet activation determines thrombus size and structure at arterial shear

Pim Kinases: Important Regulators of Cardiovascular Disease

Cucurbitacins elicit anti-platelet activity via perturbation of the actin cytoskeleton and integrin function.

Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction

Case Study: Using H5P to design and deliver interactive laboratory practicals.

Platelet-lymphocyte co-culture serves as an ex vivo platform of dynamic heterotypic cross-talk

Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling

Multiparameter phenotyping of platelet reactivity for stratification of human cohorts

Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets.

Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring.

Collaborators (16)

Stephen White

Mareike G. Posner

Marilena Crescente

Stuart Mundell

Sarah Jones

Cedric Duval

Elisabetta Liverani

Geir Ólafsson

Joanne Dunster

Hervé Falet

Mark McLaughlin

Chris Jones

Valentina Shpakova

Lisa-Marie Holbrook

Jonathan Gibbins

Alexander Bye

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