Amir Keshmiri

The low long-term patency of bypass grafts is a major concern for cardiovascular treatments. Unfavourable haemodynamic conditions in the proximity of distal anastomosis are closely related to thrombus creation and lumen lesions. Modern graft designs address this unfavourable haemodynamic environment with the introduction of a helical component in the flow field, either by means of out-of-plane helicity graft geometry or a spiral ridge. While the latter has been found to lack in performance when compared to the out-of-plane helicity designs, recent findings support the idea that the existing spiral ridge grafts can be further improved in performance through optimising relevant design parameters. In the current study, robust multi-objective optimisation techniques are implemented, covering a wide range of possible designs coupled with proven and well validated computational fluid dynamics (CFD) algorithms. It is shown that the final set of suggested design parameters could significantly improve haemodynamic performance and therefore could be used to enhance the design of spiral ridge bypass grafts.