Amit Pathak

Assistant Professor

Washington University in St. Louis

United States

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About

Dr. Amit Pathak is an Assistant Professor at Washington University in Saint Louis, USA. His research focuses on mechanisms of collective cell migration and invasion, specifically examining the roles of mechanical properties of matrices and cell interactions. Recent publications explore topics such as mechanosensing in epithelial cells, the impact of hypoxia on cancer cell behavior, and the dynamics of cell clustering and dispersal in various environments.

Articles (12)

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2025

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2025

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2025

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2025

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2025

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2023

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2023

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2023

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2023

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2023

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2022

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2021

Collaborators (2)

Jialiang Zhang

Washington University in St. Louis

UNITED STATES

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Hongsheng Yu

Washington University in St. Louis

UNITED STATES

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Amit Pathak

Research Interests

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Articles (12)

Fast yet force-effective mode of supracellular collective cell migration due to extracellular force transmission

Emergent depth-mechanosensing of epithelial collectives regulates cell clustering and dispersal on layered matrices

History of hypoxia exposure aids future cell invasion according to cell type and collagen density

Distinct roles of protrusions and collagen deformation in collective invasion of cancer cell types

Gradients in cell density and shape transitions drive collective cell migration into confining environments

Matrix obstructions cause multiscale disruption in collective epithelial migration by suppressing leader cell function

Epithelial multicellular clustering enabled by polarized macrophages on soft matrices

Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality

Reciprocal intra- and extra-cellular polarity enables deep mechanosensing through layered matrices

Nuclear export inhibition jumbles epithelial–mesenchymal states and gives rise to migratory disorder in healthy epithelia

Nucleoli in epithelial cell collectives respond to tumorigenic, spatial, and mechanical cues

Dynamic self-reinforcement of gene expression determines acquisition of cellular mechanical memory

Collaborators (2)

Jialiang Zhang

Hongsheng Yu

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