Ana Ledo

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Assistant Professor

University of Coimbra

Portugal

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About

Ana Ledo is an Assistant Professor at the University of Coimbra, Portugal. Her research focuses on neurochemical sensing, with recent publications addressing topics such as lactate and glucose biosensing in brain tissue, the roles of oxidative metabolism in neurometabolism, and advancements in amperometric sensors for real-time monitoring during neurological events. Her work contributes to the understanding of neurophysiology and therapeutic approaches in conditions such as epilepsy and Alzheimer’s disease.

Recent Grants

Grant: Close

Monitoring neurometabolic markers in vivo using microelectrode-based biosensors

Open Date: 2018-07-01

Close Date: 2021-07-01

Grant: Close

Cognitive enhancement in aged brain and vascular dementia in humans through improving neurovascular coupling: a mechanism based approach driven by nitrite and ascorbic acid from diet

Open Date: 2018-07-01

Close Date: 2021-07-01

Grant: Close

Nitric oxide is a master regulator of brain energetic metabolism: resolving aerobic glycolysis

Open Date: 2013-07-03

Close Date: 2015-09-30

Grant: Close

Nitric oxide is a master regulator of brain energetic metabolism: resolving aerobic glycolysis

Open Date: 2013-07-01

Close Date: 2015-09-01

Grant: Close

Hypercholesterolemia as a risk factor for Alzheimer’s Disease: impact on nitric oxide bioavailability and bioactivity

Open Date: 2013-04-01

Close Date: 2015-03-01

Articles (13)

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2025

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2024

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2024

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2020

Collaborators (6)

Christopher Brett

Professor Catedrático

University of Coimbra

PORTUGAL

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Gabriela Almeida

Associate Professor

Egas Moniz Cooperativa de Ensino Superior CRL

PORTUGAL

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Andreza Fabro de Bem

Visiting Professor

Linköping University

SWEDEN

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João Laranjinha

Full Professor

University of Coimbra

PORTUGAL

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Rui Barbosa

Associate Professor

Faculty of Pharmacy, University of Lisbon

PORTUGAL

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Armindo Salvador

Invited Assistant Professor

University of Coimbra

PORTUGAL

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Ana Ledo

Research Interests

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Contact this professor

About

Recent Grants

Articles (13)

Real-time neurochemical sensing of hydrogen peroxide production in brain tissue using advanced nanostructured Au microelectrodes functionalized with a ruthenium purple film

Amperometric bio-sensing of lactate and oxygen concurrently with local field potentials during status epilepticus

Redox medicine: from cellular targets to systems physiology and therapeutics

Astrocytic aerobic glycolysis provides lactate to support neuronal oxidative metabolism in the hippocampus

Modulation of oxidative neurometabolism in ischemia/reperfusion by nitrite

A Platinized Carbon Fiber Microelectrode-Based Oxidase Biosensor for Amperometric Monitoring of Lactate in Brain Slices

In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity

Highly sensitive and selective nanostructured microbiosensors for glucose and lactate simultaneous measurements in blood serum and in vivo in brain tissue

An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2‐arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease

Design and Evaluation of a Lactate Microbiosensor: Toward Multianalyte Monitoring of Neurometabolic Markers In Vivo in the Brain

A High Fat/Cholesterol Diet Recapitulates Some Alzheimer’s Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial Dysfunction

Microelectrode Sensor for Real-Time Measurements of Nitrite in the Living Brain, in the Presence of Ascorbate

Electrochemical Evaluation of a Multi-Site Clinical Depth Recording Electrode for Monitoring Cerebral Tissue Oxygen

Collaborators (6)

Christopher Brett

Gabriela Almeida

Andreza Fabro de Bem

João Laranjinha

Rui Barbosa

Armindo Salvador

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