Andreas Reichel

VP, Head

Bayer AG

Germany

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Andreas Reichel serves as the Vice President and Head at Bayer AG in Germany. His research focuses on pharmacokinetics and pharmacodynamics, particularly in the context of targeted protein degraders and small molecule development. Recent publications include works on predictive modeling for drug distribution and evaluating renal excretion using kidney cells. Additionally, he has contributed to the understanding of tissue distribution models and their implications for drug discovery.

Articles (10)

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2024

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2023

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2023

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2022

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2022

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2021

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2021

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2020

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2020

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2020

Collaborators (2)

Irena Loryan

Associate Professor, PI, Researcher

Uppsala University

SWEDEN

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Panteleimon Mavroudis

Distinguished Scientist - US Head of Quantitative Pharmacology Research

Sanofi

UNITED STATES

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Andreas Reichel

Research Interests

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Articles (10)

Transforming the Discovery of Targeted Protein Degraders: The Translational Power of Predictive PK/PD Modeling

Trends in Molecular Properties, Bioavailability, and Permeability across the Bayer Compound Collection

A Mechanistic Pharmacodynamic Modeling Framework for the Assessment and Optimization of Proteolysis Targeting Chimeras (PROTACs)

Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.

Potential and Limits of Kidney Cells for Evaluation of Renal Excretion

Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat

Concentration Dependence of the Unbound Partition Coefficient Kpuu and Its Application to Correct for Exposure-Related Discrepancies between Biochemical and Cellular Potency of KAT6A Inhibitors

Concentration dependence of the unbound partition coefficient Kp<sub>uu</sub>and its application to correct for exposure-related discrepancies between biochemical and cellular potency of KAT6A inhibitors

Systematic analysis of the whole-body tissue distribution and fatty acid compositions of membrane lipids in CD1 and NMRI mice and Wistar rats

Collaborators (2)

Irena Loryan

Panteleimon Mavroudis

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