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Andreas Rummel

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Hannover Medical School

Germany

Research Interests

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Professors in Germany Professors in Biochemistry Biochemistry professors in Germany

Recent Grants

Grant: Close

Alternativmethoden: Implementierung einer routinefähigen Tierversuchsersatzmethode für die Botulinum Neurotoxin-Diagnostik (ImpliBoNT) - Rezeptor-basierte Diagnostika für BoNT/E

Open Date: 2023-04-01

Close Date: 2026-03-31

Grant: Close

Verbundprojekt: Erforschung und Herstellung eines dekavalenten Botulismus-Antitoxins zur Abwehr von bioterroristischen Gefahrenlagen (X-BAT) - Teilvorhaben: Erforschung und rekombinante Herstellung von zehn Botulinum Neurotoxin Toxoiden als Impfantigene zur Herstellung eines dekavalenten Botulismus-Antitoxins

Open Date: 2021-03-01

Close Date: 2025-12-31

Grant: Close

Alternativmethoden zum Tierversuch - Verbund: TiViBoNT - Eine Tierversuchsersatzmethode für die BoNT-Diagnostik - TP 2

Open Date: 2018-05-01

Close Date: 2022-04-30

Grant: Close

EuroBioTox: European programme for the establishment of validated procedures for the detection and identification of biological toxins.

Open Date: 2017-06-01

Close Date: 2022-05-01

Grant: Close

Verbundprojekt: Sensor-basierte und automatisierte Detektion von hoch- und niedermolekularen biologischen Toxinen (SensTox) - Teilvorhaben: Erforschung von innovativen Bindungs- und Detektionskonzepten für Clostridium perfringens Entero- und Epsilontoxine sowie der Staphylococcus aureus Enterotoxine

Open Date: 2015-12-01

Close Date: 2019-05-31

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Collaborators (9)

Martin Dorner

Robert Koch Institute

GERMANY

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Vanessa Lanoue

Head

Victor Chang Cardiac Research Institute

AUSTRALIA

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Geoffrey Masuyer

Senior Research Scientist

Stockholm University

SWEDEN

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Maria Barbara Nowakowska

University of Helsinki

FINLAND

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Frédéric A Meunier

AUSTRALIA

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Bettina Seeger

Junior Professor for Alternative/Complementary Methods to Animal Experiments

University of Veterinary Medicine Hannover, Foundation

GERMANY

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Rongsheng Jin

UNITED STATES

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Pål Stenmark

Professor

Stockholm University

SWEDEN

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Daniel Stern

Robert Koch Institute

GERMANY

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Andreas Rummel

Research Interests

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Recent Grants

Articles (20)

High sensitivity of iPSC-derived motor neurons to the human-relevant botulinum neurotoxin serotypes E and F

A belt-buckle checkpoint regulates the onset of botulinum neurotoxin intoxication

Assembly of Medium Progenitor Toxin Complexes and HA Complexes Into a Large Botulinum Neurotoxin Complex

Cloning, Expression, Purification and Characterization of the Twelve Subtypes of Botulinum Neurotoxin E1-E12

Design of Novel Fusion Receptor Proteins to Enable Specific Binding of Botulinum Neurotoxins in a Native-like Membrane Environment

A nut-and-bolt assembly of the bimodular large progenitor botulinum neurotoxin complex

Botulinum neurotoxin A mutants with enhanced ganglioside binding show improved potency and altered ganglioside selectivity

Highly Sensitive Suspension Immunoassay for Multiplex Detection, Differentiation, and Quantification of Eight <i>Staphylococcus aureus</i> Enterotoxins (SEA to SEI)

<i>N</i>-Glycosylation Profile of Abrin Certified EU Reference Material

Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47

Validation of an Endopep-Suspension Immunoassay for the Diagnostics of Human Botulism

An Endopeptidase Suspension Immunoassay for the Detection of BoNT-A and -B in Botulism Patient Sera

Comparative Analysis of Botulinum Neurotoxin A and B Subtypes

Design and Production of Full-Length, Biologically Inactive Botulinum Neurotoxin Serotypes to Serve as Natively Folded Antigens for Antitoxin Generation

Design of a Soluble, Full-Length SV2A Using the QTYCode for Binding of BoNTs-A and -E

Mimicking the Multivalent Binding of Bacterial Protein Toxins to Their Cellular Receptors in a Native-Like Membrane Environment

Recombinant Expression of BoNT Molecules in <i>E coli</i> and Determination of Biological Activity by ex vivo Mouse Phrenic Nerve Hemidiaphragm Assay

Crystal structures of OrfX1, OrfX2 and the OrfX1–OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1

Presynaptic targeting of botulinum neurotoxin type A requires a tripartite <scp>PSG‐Syt1</scp>‐<scp>SV2</scp> plasma membrane nanocluster for synaptic vesicle entry

Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2

Collaborators (9)

Martin Dorner

Vanessa Lanoue

Geoffrey Masuyer

Maria Barbara Nowakowska

Frédéric A Meunier

Bettina Seeger

Rongsheng Jin

Pål Stenmark

Daniel Stern

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