Andres Aguilera

Genetics Professor

Universidad de Sevilla

Spain

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About

Andres Aguilera is a Genetics Professor at the University of Seville, Spain. His research primarily focuses on the molecular mechanisms of genome stability, with recent work exploring transcription-replication conflicts, R-loop dynamics, and the role of RNA-binding proteins in genome integrity. He has contributed significantly to our understanding of S-phase checkpoints and transcription-coupled DNA repair mechanisms.

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Collaborators (17)

Ralf Erik Wellinger

Full Professor

Universidad de Sevilla

SPAIN

Andres Aguilera

Research Interests

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About

Articles (22)

Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer

S-phase checkpoint protects from aberrant replication fork processing and degradation

Cellular imbalance of specific RNA-binding proteins associates with harmful R-loops

R-loop homeostasis in genome dynamics, gene expression and development

Human DNA topoisomerase I poisoning causes R loop–mediated genome instability attenuated by transcription factor IIS

Histone variant H2A.Z is needed for efficient transcription-coupled NER and genome integrity in UV challenged yeast cells

RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity

Rat1 promotes premature transcription termination at R-loops

SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability

The molecular chaperone ALYREF promotes R-loop resolution and maintains genome stability

Break‐induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?

The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts

A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability

WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage

A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells.

A CDK-regulated chromatin segregase promoting chromosome replication

The role of chromatin at transcription-replication conflicts as a genome safeguard

VID22 counteracts G-quadruplex-induced genome instability

THSC/TREX-2 deficiency causes replication stress and genome instability in Caenorhabditis elegans

R-Loop–Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin

Harmful R-loops are prevented via different cell cycle-specific mechanisms

DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

Collaborators (17)

Ralf Erik Wellinger

Rebecca Dagg

Belen Gomez-Gonzalez

Felix Mueller-Planitz

Thanos Halazonetis

agnes basseville

Alan Cheung

Peter Askjaer

Yatin Vyas

Emilia Puig Lombardi

Francisco Antequera

Xiaoyu Xue

Giovanni Capranico

Federico Lazzaro

Rosa Mª Luna Varo

Tatiana Garcia-Muse

Maryam Safari

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