Andrew Bennet

Professor

Simon Fraser University

Canada

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About

Professor Andrew Bennet is a faculty member at Simon Fraser University in Canada. His research primarily focuses on the enzymatic mechanisms of glycoside hydrolases and their interactions with various substrates, as well as the catalytic properties of DNA-based enzymes. Recent work includes studies on covalent intermediates with galactosidases and the hydrolysis of glycosides, contributing to a deeper understanding of carbohydrate-active enzymes.

Articles (11)

Year:

2024

Year:

2022

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2022

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2021

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2021

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2021

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2021

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2021

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2020

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2020

Year:

2020

Collaborators (2)

Lukasz Sobala

Assistant Professor

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences

POLAND

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Robert Britton

Simon Fraser University

CANADA

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Andrew Bennet

Research Interests

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Articles (11)

Mechanism-Based Allylic Carbasugar Chlorides That Form Covalent Intermediates with α- and β-Galactosidases

A Mechanistic Study on the Non-enzymatic Hydrolysis of Kdn Glycosides

Glycoside Hydrolase Catalysis: Do Substrates and Mechanism-Based Covalent Inhibitors React via Matching Transition States?

A heme•DNAzyme activated by hydrogen peroxide catalytically oxidizes thioethers by direct oxygen atom transfer rather than by a Compound I-like intermediate

Fundamental Insight into Glycoside Hydrolase-Catalyzed Hydrolysis of the Universal Koshland Substrates-Glycopyranosyl Fluorides

Intrinsic Nucleophilicity of Inverting and Retaining Glycoside Hydrolases Revealed Using Carbasugar Glyco-Tools

Kinetic and Structural Characterization of Sialidases (Kdnases) from Ascomycete Fungal Pathogens

Structurally homologous sialidases exhibit a commonality in reactivity: Glycoside hydrolase-catalyzed hydrolysis of Kdn-thioglycosides

An Epoxide Intermediate in Glycosidase Catalysis

Conformationally Controlled Reactivity of Carbasugars Uncovers the Choreography of Glycoside Hydrolase Catalysis

Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design

Collaborators (2)

Lukasz Sobala

Robert Britton

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