Andrew Murray

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Reader in Metabolic Physiology

University of Cambridge

United Kingdom

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Andrew Murray is a Reader in Metabolic Physiology at the University of Cambridge, UK. His research primarily focuses on metabolic health, the physiological adaptations to hypoxia, and mitochondrial function related to various conditions, including obesity and pregnancy. Recent articles authored by Dr. Murray explore topics such as the effects of inorganic nitrate supplementation, ageing-related pathologies, and metabolic responses to surgical interventions.

Recent Grants

Grant: Close

Cardiovascular Effects of Incretins and Other Peptide Hormones

Open Date: 2017-01-01

Close Date: 2019-01-01

Grant: Close

Developmental Regulation of Mitochondrial Function

Open Date: 2017-01-01

Close Date: 2020-01-01

Grant: Close

Drug Induced Mitochondrial Toxicity in the Context of Hypoxia

Open Date: 2016-01-01

Close Date: 2019-01-01

Grant: Close

Celular Energetics and Human Disease

Open Date: 2016-01-01

Close Date: 2019-01-01

Grant: Close

The Relationship Between Oxidative Stress, Mitochondrial Function and Postoperative Outcomes in High Risk Patients Undergoing Major Surgery

Open Date: 2016-01-01

Close Date: 2018-01-01

Articles (28)

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2025

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2025

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2025

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2025

Hypoxia-inducible factor pathway genes are linked to adaptation in both human and nonhuman highland species. EPAS1 , a notable target of hypoxia adaptation, is associated with relatively lower hemoglobin concentration in Tibetans. We provide evidence for an association between an adaptive EPAS1 variant (rs570553380) and the same phenotype of relatively low hematocrit in Andean highlanders. This Andean-specific missense variant is present at a modest frequency in Andeans and absent in other human populations and vertebrate species except the coelacanth. CRISPR-base-edited human cells with this variant exhibit shifts in hypoxia-regulated gene expression, while metabolomic analyses reveal both genotype and phenotype associations and validation in a lowland population. Although this genocopy of relatively lower hematocrit in Andean highlanders parallels well-replicated findings in Tibetans, it likely involves distinct pathway responses based on a protein-coding versus noncoding variants, respectively. These findings illuminate how unique variants at EPAS1 contribute to the same phenotype in Tibetans and a subset of Andean highlanders despite distinct evolutionary trajectories.

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2024

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2024

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2024

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2021

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2021

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2021

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2021

Collaborators (37)

Beth Allison

MONASH UNIVERSITY

AUSTRALIA

Andrew Murray

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Recent Grants

Articles (28)

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The effects of major abdominal surgery on skeletal muscle mitochondrial respiration in relation to systemic redox status and cardiopulmonary fitness

Chronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity

Mitochondrial Sensitivity to Submaximal [ADP] Following Bed Rest: A Novel Two-Phase Approach Associated With Fibre Types

Functional <i>EPAS1</i> / <i>HIF2A</i> missense variant is associated with hematocrit in Andean highlanders

Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial

Beta-adrenergic agonism protects mitochondrial metabolism in the pancreatectomised rat heart

Genomic Selection Signals in Andean Highlanders Reveal Adaptive Placental Metabolic Phenotypes That Are Disrupted in Preeclampsia

Programming of cardiac metabolism by miR-15b-5p, a miRNA released in cardiac extracellular vesicles following ischemia-reperfusion injury

Defining an ageing-related pathology, disease or syndrome: International Consensus Statement

Author Correction: Limited oxygen in standard cell culture alters metabolism and function of differentiated cells.

Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas.

Developmental programming of mitochondrial substrate metabolism in skeletal muscle of adult sheep by cortisol exposure before birth

Glucagon and exenatide improve contractile recovery following ischaemia/reperfusion in the isolated perfused rat heart

The metabolic response of human trophoblasts derived from term placentas to metformin

Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19

Lipidomic Approaches to Study HDL Metabolism in Patients with Central Obesity Diagnosed with Metabolic Syndrome

Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation

Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation

Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

Development of cerebral mitochondrial respiratory function is impaired by thyroid hormone deficiency before birth in a region-specific manner

Development of cerebral mitochondrial respiratory function is impaired by thyroid hormone deficiency before birth in a region‐specific manner

Editorial: Translational Approaches for Targeting Cardiovascular Complications of Diabetes

Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress

Glucocorticoid maturation of mitochondrial respiratory capacity in skeletal muscle before birth

Hypoxia-Inducible Factors as Key Players in the Pathogenesis of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

The association of circulating amylin with β-amyloid in familial Alzheimer's disease

Collaborators (37)

Beth Allison

Claire Stewart

Anthony Shepherd

Julian Griffin

Bernadette Fernandez

Maria Perissiou

Johannes Attems

Kimberley J. Botting-Lawford

Gregory Jicha

Alison Forhead

Christopher Plack

Katie Alice O'Brien

A L Fowden

Zoe Saynor

Irving L. M. H. Aye

Peter Weijs

Venkateswarlu Kanamarlapudi

David John Clancy

Rahul Bhatnagar

Daniel Martin

Willem Wiersinga

Claudia Metzler-Baddeley

D. Stephen Charnock-Jones

Christopher George

Keeron Stone

nirmal verma

Karen Forbes

Rebecca Neal

Gordon Smith

William Parry-Smith

Antonio Moschetta

Michael P. W. Grocott

James Alexander Nathan

Carl Sheridan

Tatum S. Simonson

Heather Massey

Elie Naddaf

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