Angelo SPINELLO

Assistant Professor

University of Palermo

Italy

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Angelo Spinello is an Assistant Professor at the University of Palermo, Italy. His research focuses on the development of small-molecule modulators for cancer treatments, particularly in the context of breast cancer and spliceosome-mutant cancers. He employs computational and structural biology techniques, alongside all-atom simulations, to investigate the molecular mechanisms of drug interactions and disease processes.

Articles (10)

Year:

2023

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2022

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2021

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2021

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2021

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2021

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2021

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2021

Year:

2021

Year:

2021

Collaborators (4)

Eleonora Turrini

University of Bologna

ITALY

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Alessandra Bisi

University of Bologna

ITALY

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Nadia Zaffaroni

Head of Research Unit (Molecular Pharmacology)

Fondazione IRCCS Istituto Nazionale dei Tumori

ITALY

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Federica Belluti

ALMA MATER STUDIORUM UNIVERSITY OF BOLOGNA

ITALY

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Angelo SPINELLO

Research Interests

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Articles (10)

Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment

Role of computational and structural biology in the development of small-molecule modulators of the spliceosome

Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer

Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers

All-atom simulations to studying metallodrugs/target interactions

Allosteric Cross-Talk among Spike’s Receptor-Binding Domain Mutations of the SARS-CoV-2 South African Variant Triggers an Effective Hijacking of Human Cell Receptor

Computing Metal-Binding Proteins for Therapeutic Benefit

Frontiers of metal-coordinating drug design

Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations

Molecular Mechanisms of the Blockage of Glioblastoma Motility

Collaborators (4)

Eleonora Turrini

Alessandra Bisi

Nadia Zaffaroni

Federica Belluti

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