Anna Pasternak

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Head of Department

Institute of Bioorganic Chemistry PAS

Poland

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Recent Grants

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Foldback triplex-forming oligonucleotides as novel tools for G-quadruplex unfolding and selective inhibition of c-Myc oncogene transcription

Open Date: 2021-04-01

Close Date: 2025-03-01

Grant: Close

Uwarunkowania strukturalne właściwości przeciwnowotworowych oligonukleotydów bogatych w guanozynę

Open Date: 2018-01-30

Close Date: 2021-01-29

Grant: Close

Termodynamiczne podstawy projektowania optymalnych funkcjonalnie, modyfikowanych siRNA oraz ich eksperymentalna weryfikacja.

Open Date: 2014-07-02

Close Date: 2018-04-01

Grant: Close

Nowe 3,8-dipodstawione analogi nukleozydów purynowych o potencjalnym zastosowaniu w badaniach strukturalnych i aktywności biologicznej kwasów nukleinowych

Open Date: 2013-02-07

Close Date: 2016-02-06

Articles (10)

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2020

Collaborators (2)

Jesper Wengel

Professor

University of Southern Denmark

DENMARK

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Ryszard Kierzek

Institute of Bioorganic Chemistry Polish Academy of Sciences

POLAND

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Anna Pasternak

Research Interests

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Recent Grants

Articles (10)

Bispecific G-quadruplexes as inhibitors of cancer cells growth

Physicochemical and antiproliferative characteristics of RNA and DNA sequence-related G-quadruplexes

A Structural Potential of Rare Trinucleotide Repeat Tracts in RNA

Optimization of Bifunctional Antisense Oligonucleotides for Regulation of Mutually Exclusive Alternative Splicing of PKM Gene

Changes in physicochemical and anticancer properties modulated by chemically modified sugar moieties within sequence-related G-quadruplex structures

Evaluation of Gene Expression Knock‐Down by Chemically and Structurally Modified Gapmer Antisense Oligonucleotides

A Comprehensive Analysis of the Thrombin Binding Aptamer Containing Functionalized Pyrrolo-2’-deoxycytidines

Beyond G-Quadruplexes—The Effect of Junction with Additional Structural Motifs on Aptamers Properties

G4 Matters—The Influence of G-Quadruplex Structural Elements on the Antiproliferative Properties of G-Rich Oligonucleotides

Gapmer Antisense Oligonucleotides Containing 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐C‐hydroxymethyl‐β‐d‐lyxofuranosyl Nucleotides Display Site‐Specific RNase H Cleavage and Induce Gene Silencing

Collaborators (2)

Jesper Wengel

Ryszard Kierzek

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