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Anne Grünewald

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Full Professor

University of Luxembourg

Luxembourg

Research Interests

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Recent Grants

Grant: Open

RiboPD: The role of ribosome speed control in the pathogenesis of Parkinson's disease

Open Date: 2026-01-01

Close Date: 2029-01-01

Grant: Open

mitoERsgnl: The role of ER-mitochondria signalling in Parkin-associated Parkinson´s disease

Open Date: 2025-01-01

Close Date: 2027-01-01

Grant: Open

MitoDefinePD: Mitochondrial signalling at the interface of genetics and environment in Parkinson’s disease

Open Date: 2025-01-01

Close Date: 2028-01-01

Grant: Open

MITO-MANIAK: Modelling mitochondrial metabolism at the interface of astrocytes and neurons to uncover novel treatment strategies for Parkinson's disease

Open Date: 2025-01-01

Close Date: 2028-01-01

Grant: Open

FUN-MITO: Functional validation of mitochondrial polygenic risk scores in the PPMI cohort

Open Date: 2025-01-01

Close Date: 2027-01-01

Articles (19)

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2022

Collaborators (20)

Alessandro Michelucci

Group Leader

Luxembourg Institute of Health

LUXEMBOURG

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Cláudia Saraiva

Chaire de professeur junior (CPJ)

Université de Bourgogne

FRANCE

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Jens C. Schwamborn

Professor

LUXEMBOURG

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Peter P Pramstaller

Head of Institute

Eurac Research

ITALY

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Gizem Onal

University of Oxford

UNITED KINGDOM

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Michel Mittelbronn

FNR PEARL Chair

University of Luxembourg

LUXEMBOURG

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Patrick May

Senior Researcher, Head of Genome Analysis

University of Luxembourg

LUXEMBOURG

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Elsa Leitão

Universitätsklinikum Essen Institut für Humangenetik

GERMANY

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Philip Seibler

GERMANY

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Paul Wieringa

University of Maastricht

NETHERLANDS

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Ioannis Charalampopoulos

Researcher

University of Crete School of Medicine

GREECE

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Corrado Calì

Associate Professor

University of Turin

ITALY

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Nathalie Legrave

Head of Metabolomics platform

Luxembourg Institute of Health

LUXEMBOURG

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Irene Pichler

Senior Researcher

Eurac Research

ITALY

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Christine Klein

University of Lübeck

GERMANY

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Thorsten Schmidt

Group leader

University of Tübingen

GERMANY

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Bieke Broux

Hasselt University

BELGIUM

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Alexandros Lavdas

Senior Researcher, Neuroscience/Imaging

Eurac Research

ITALY

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Matthieu Lavigne

Group leader of the Gene Control Mechanisms group and head of Genomics Facility

GREECE

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Ivo Lambrichts

Prof.dr

BELGIUM

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Anne Grünewald

Research Interests

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Recent Grants

Articles (19)

Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons

Blood mtDNA markers of mitochondrial subtype and early-onset Parkinson’s disease biology

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Large-scale copy number variant analysis in genes linked to Parkinson´s disease.

Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss.

Methodological validation of Miro1 retention as a candidate Parkinson’s disease biomarker

Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity

PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation

Exploring environmental modifiers of LRRK2-associated Parkinson’s disease penetrance: An exposomics and metagenomics pilot study on household dust

Polygenic Risk Scores Validated in Patient‐Derived Cells Stratify for Mitochondrial Subtypes of Parkinson's Disease

DYT-THAP1: exploring gene expression in fibroblasts for potential biomarker discovery

Genome-wide case-only analysis of gene-gene interactions with known Parkinson’s disease risk variants reveals link between LRRK2 and SYT10

Molecular phenotypes of mitochondrial dysfunction in clinically non-manifesting heterozygous PRKN variant carriers.

Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.1290A > G (p.T351A) or c.2067A > G (p.T610A) in the RHOT1 gene encoding Miro1.

Mitochondria–Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1‐PD or PRKN‐PD Neurons

Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1

From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions

Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease

Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.

Collaborators (20)

Alessandro Michelucci

Cláudia Saraiva

Jens C. Schwamborn

Peter P Pramstaller

Gizem Onal

Michel Mittelbronn

Patrick May

Elsa Leitão

Philip Seibler

Paul Wieringa

Ioannis Charalampopoulos

Corrado Calì

Nathalie Legrave

Irene Pichler

Christine Klein

Thorsten Schmidt

Bieke Broux

Alexandros Lavdas

Matthieu Lavigne

Ivo Lambrichts

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