Anthony Fehr

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Associate Professor

University of Kansas

United States

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Anthony Fehr is an Associate Professor at the University of Kansas, USA. His research focuses on viral replication cycles, particularly in relation to coronaviruses and Pseudomonas aeruginosa. Recent articles highlight his work on SARS-CoV-2 Mac1 inhibitors and the impact of quorum sensing regulation on pathogenicity.

Recent Grants

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Deciphering the Role of the Coronavirus Macro Domain in SARS-CoV Infection

Open Date: 2014-12-25

Close Date: 2015-12-24

Articles (15)

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Collaborators (10)

Diane Griffin

Johns Hopkins University

UNITED STATES

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Jürgen Bosch

Case Western Reserve University

UNITED STATES

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Matthew T. Cabeen

Oklahoma State University

UNITED STATES

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Xufang Deng

Assistant professor

Oklahoma State University

UNITED STATES

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David J. Davido

University of Kansas

UNITED STATES

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Matthias Salathe

University of Kansas Medical Center

UNITED STATES

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Chengjin Ye

Texas Biomedical Research Institute

UNITED STATES

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Susan R. Weiss

University of Pennsylvania Perelman School of Medicine

UNITED STATES

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Robin Orozco

Assistant Professor

University of Kansas

UNITED STATES

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Dana Ferraris

Associate Professor of Chemistry, Department Chair

McDaniel College

UNITED STATES

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Anthony Fehr

Research Interests

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About

Recent Grants

Articles (15)

Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle

Quorum sensing regulation by the nitrogen phosphotransferase system in Pseudomonas aeruginosa

IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice

SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice

PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner

Two Commercially Available Blood-Stabilization Reagents Serve as Potent Inactivators of Coronaviruses

Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles

An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors

Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening

PARP14: A key ADP-ribosylating protein in host–virus interactions?

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells

Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain.

The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses

High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain.

Collaborators (10)

Diane Griffin

Jürgen Bosch

Matthew T. Cabeen

Xufang Deng

David J. Davido

Matthias Salathe

Chengjin Ye

Susan R. Weiss

Robin Orozco

Dana Ferraris

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