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Antonio F Ambrósio

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Coordinating Investigator / Full Professor

University of Coimbra

Portugal

Research Interests

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Recent Grants

Grant: Close

Retinal Optical Coherence Tomography-derived texture features as potential biomarkers for early diagnosis and progression of diabetic retinopathy

Open Date: 2025-01-01

Close Date: 2025-12-01

Grant: Close

"EYS on" gene editing for Retinitis Pigmentosa 25

Open Date: 2024-04-01

Close Date: 2026-03-01

Grant: Close

Microsponge for intravitreal therapy of age-related macular degeneration and diabetic retinopathy

Open Date: 2023-10-01

Close Date: 2024-10-01

Grant: Close

N(DR)2-Eye - Ndr2 kinase: a novel player in the regulation of microglia in diabetic retinopathy

Open Date: 2023-03-01

Close Date: 2024-10-01

Grant: Close

Deciphering the role of Piezo1 mechanosensitive channel in microglia-mediated glaucomatous neurodegeneration

Open Date: 2023-03-01

Close Date: 2026-03-01

Articles (20)

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2026

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2025

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2025

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2025

Kinases play crucial roles in the pathophysiology of retinal degenerative diseases. These diseases, such as diabetic retinopathy, age-related macular degeneration, glaucoma, and retinitis pigmentosa, are characterized by progressive degeneration of retinal cells, including photoreceptors, ganglion cells, vascular cells, and retinal pigment epithelium, among others. The involvement of kinases in cell survival and apoptosis, immune responses and inflammation regulation, mitochondrial functions and mitophagy, autophagy, and proteostasis is crucial for maintaining cellular homeostasis and responding to various stressors. This review highlights the importance of studying kinases to better understand their functions and, regulation permitting, enable the identification of novel molecular players or potential drug targets and, consequently, the development of more effective and precise treatments to slow or halt the progression of retinal degenerative diseases.

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2024

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2023

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2023

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2023

Collaborators (28)

Paulo Santos

Associate Professor

University of Coimbra

PORTUGAL

Antonio F Ambrósio

Research Interests

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Recent Grants

Articles (20)

Comparison of TonoLab, TonoVet Plus, and Tono‐Pen AVIA Vet Tonometers for Measuring Intraocular Pressure in Rats

Inflammatory Biomarkers in Diabetic Macular Edema

Retinal OCT-Derived Texture Features as Potential Biomarkers for Early Diagnosis and Progression of Diabetic Retinopathy

Genetic Landscape of Nonsyndromic Retinitis Pigmentosa in Portugal

NDR2 Kinase Regulates Microglial Metabolic Adaptation and Inflammatory Response: Critical Role in Glucose-Dependent Functional Plasticity

Early life behavioral deficits and microglia remodeling in the mesocorticolimbic system precede the emergence of Schizophrenia-like symptoms

Clinical and Histopathologic Findings in Jalili Syndrome

The Importance of Kinases in Retinal Degenerative Diseases

Müller glial cells located in the peripheral retina are more susceptible to high pressure: implications for glaucoma

Tracing the influence of prenatal risk factors on the offspring retina: Focus on development and putative long‐term consequences

Contribution of extracellular vesicles for the pathogenesis of retinal diseases: shedding light on blood-retinal barrier dysfunction

Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease

Retinal imaging in animal models: Searching for biomarkers of neurodegeneration

Eyes Shut Homolog-Associated Retinal Degeneration: Natural History, Genetic Landscape, and Phenotypic Spectrum

Attention-Deficit/Hyperactivity Disorder Animal Model Presents Retinal Alterations and Methylphenidate Has a Differential Effect in ADHD versus Control Conditions

Self-reported visual function and psychosocial impact of visual loss in <i>EYS</i>-associated retinal degeneration in a Portuguese population.

Neuroinflammation and gliosis in the injured and contralateral retinas after unilateral optic nerve crush

Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance

Maternal diabetes affects rat offspring retinal structure and function: Sex-specific vulnerabilities at infancy

The NDR/LATS protein kinases in neurobiology: Key regulators of cell proliferation, differentiation and migration in the ocular and central nervous system

Collaborators (28)

Paulo Santos

Rui Bernardes

Peter M. J. Quinn

Hélène Léger

Marta Agudo-Barriuso

Ana Raquel Santiago

Carlos Fontes Ribeiro

António Miguel Morgado

Maria Filomena Botelho

Pedro Serranho

Rufino Silva

Rosa Fernandes

Carlos Marques Neves

Elisa Julião Campos

João P Figueira

Pedro Guimarães

Jorge Manuel Saraiva

Carlos Miguel Marto

Francisco Caramelo

CARIDAD GALINDO-ROMERO

Celso Henrique Alves

Camila Portugal

Nuno Alexandre

Cord Brakebusch

Ana Paula Silva

Renato Socodato

Elena Vecino

Paulo Rodrigues-Santos

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