Antony Michealraj Kulandai Manuvel

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Assistant Professor (Tenure-Track)

University of Pittsburgh

United States

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About

Antony Michealraj Kulandai Manuvel is an Assistant Professor (Tenure-Track) at the University of Pittsburgh, USA. His research focuses on cancer biology, particularly in medulloblastoma, ependymoma, and pediatric gliomas, exploring the mechanisms of tumor formation and the role of cancer stem cells. His recent publications include investigations into the context-dependent drivers of medulloblastoma and the epigenetic regulation of gliomas.

Recent Grants

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Treating the Untreatable: Targeting Paediatric Brain Tumours with Multi-omics and Drug Discovery

Open Date: 2018-09-01

Close Date: 2020-08-01

Articles (13)

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2020

Collaborators (15)

Daniel Schramek

Associate Professor

University of Toronto

CANADA

Antony Michealraj Kulandai Manuvel

Research Interests

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About

Recent Grants

Articles (13)

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip

An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma

Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma

TULIPs decorate the three-dimensional genome of PFA ependymoma

Epigenetically active chromatin in neonatal iWAT reveals GABPα as a potential regulator of beige adipogenesis

Protocol for the derivation of primary cancer stem cell lines from human ependymal tumors

Targeting mitochondrial energetics reverses panobinostat‐ and marizomib‐induced resistance in pediatric and adult high‐grade gliomas

3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma

A noncoding single-nucleotide polymorphism at 8q24 drives <i>IDH1</i>-mutant glioma formation.

A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours

Pediatric posterior fossa ependymoma and metabolism: A narrative review

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

Collaborators (15)

Daniel Schramek

Owen Chapman

Jose Javier Hernandez

SAMEER AGNIHOTRI

Pim French

John Joo Yiul Lee

Jennifer Chan

Alexej Abyzov

Laura Donovan

Panagiotis Prinos

Daniel Murphy

Marco Gallo

Geneviève Deblois

Taylor Gatesman

Sujith Joseph

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