Arthur Van Aerschot

Professor

KU Leuven

Belgium

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About

Arthur Van Aerschot is a Professor at KU Leuven in Belgium, where he specializes in the fields of aminoacyl-tRNA synthetases and drug discovery. His recent research includes studying the structural basis of enzyme inhibition and the development of novel inhibitors for various therapeutic targets. He is particularly focused on the synthesis and evaluation of druggable compounds aimed at improving antimicrobial treatments.

Articles (8)

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Year:

2020

Collaborators (6)

Martin Juhás

Univerzita Karlova Farmaceutická Fakulta v Hradci Králové

CZECH REPUBLIC

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Jan Zitko

Charles University

CZECH REPUBLIC

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Ita Gruic‐Sovulj

CROATIA

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Sergei Strelkov

associate professor, professor, full professor

KU Leuven

BELGIUM

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Jef Rozenski

professor

KU Leuven

BELGIUM

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Frank von Delft

University of Oxford

UNITED KINGDOM

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Arthur Van Aerschot

Research Interests

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Articles (8)

Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides

Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip

Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors

Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies

Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery

Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors

Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors

Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases

Collaborators (6)

Martin Juhás

Jan Zitko

Ita Gruic‐Sovulj

Sergei Strelkov

Jef Rozenski

Frank von Delft

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