Artur Indzhykulian

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Assistant Professor

Massachusetts Eye and Ear, Harvard Medical School

United States

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About

Artur Indzhykulian is an Assistant Professor at Harvard Medical School and the Massachusetts Eye and Ear Infirmary in the United States. His research focuses on auditory biology, particularly in the areas of cochlear hair cell functionality, regeneration techniques, and the genetic basis of hearing loss. Recent articles authored by him explore topics such as gene therapy applications for hearing restoration and the mechanisms underlying stereocilia maintenance and B cell lymphoma.

Recent Grants

Grant: Open

Development of Gene Therapy for Hereditary Deafness using Rational Protein Engineering

Open Date: 2022-06-17

Close Date: 2027-05-31

Grant: Close

Molecular Basis of Hair Cell Stereocilia Bundle Morphology

Open Date: 2018-08-01

Close Date: 2023-07-31

Articles (12)

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2021

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2021

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2021

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2020

Collaborators (8)

Benjamin Kleinstiver

Assistant Professor

Harvard Medical School

UNITED STATES

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Yan Hu

Harvard University

UNITED STATES

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Runjia Cui

National Institutes of Health

UNITED STATES

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Marcos Sotomayor

Ohio State University

UNITED STATES

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Lavinia Sheets

Assistant Professor

Washington University in Saint Louis School of Medicine

UNITED STATES

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Albert Edge

Professor

Massachusetts Eye and Ear

UNITED STATES

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Srinivasvinod Saladi

Assistant Professor

Harvard Medical School

UNITED STATES

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Mark Warchol

Professor

Washington University School of Medicine

UNITED STATES

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Artur Indzhykulian

Research Interests

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Recent Grants

Articles (12)

PKHD1L1 is required for stereocilia bundle maintenance, durable hearing function and resilience to noise exposure

Age-associated clonal B cells drive B cell lymphoma in mice.

Large-scale annotated dataset for cochlear hair cell detection and classification.

PKHD1L1, a gene involved in the stereocilia coat, causes autosomal recessive nonsyndromic hearing loss.

Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F.

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice

Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F

The hair cell analysis toolbox is a precise and fully automated pipeline for whole cochlea hair cell quantification

Mechanical overstimulation causes acute injury and synapse loss followed by fast recovery in lateral-line neuromasts of larval zebrafish

Norrie disease protein is essential for cochlear hair cell maturation

Electron Microscopy Techniques for Investigating Structure and Composition of Hair-Cell Stereociliary Bundles.

Serial scanning electron microscopy of anti-PKHD1L1 immuno-gold labeled mouse hair cell stereocilia bundles

Collaborators (8)

Benjamin Kleinstiver

Yan Hu

Runjia Cui

Marcos Sotomayor

Lavinia Sheets

Albert Edge

Srinivasvinod Saladi

Mark Warchol

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