Artur Krężel

Professor, head of Department of Chemical Biology

University of Wrocław

Poland

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About

Artur Krężel is a Professor and the head of the Department of Chemical Biology at the University of Wrocław. His research focuses on biochemical and cellular mechanisms in T cells, as well as the study of metallothioneins and their interactions with metals, particularly zinc and copper. He has published recent articles examining the binding affinities of metallothioneins and the application of mass spectrometry techniques in understanding drug interactions and toxicity in aquatic environments. Professor Krężel's work contributes significantly to the field of chemical biology and environmental biochemistry.

Articles (24)

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2024

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2021

Collaborators (23)

Marek Luczkowski

assistant professor

University of Wrocław

POLAND

Artur Krężel

Research Interests

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Articles (24)

Phytochelatins Bind Zn(II) with Micro- to Picomolar Affinities without the Formation of Binuclear Complexes, Exhibiting Zinc Buffering and Muffling Rather than Storing Functions

Joint forces of mass spectrometric techniques (ICP-MS and MALDI-TOF-MS) and fluorescence spectrometry in the study of platinum-based cytostatic drugs interactions with metallothionein MT2 and MT3

A combined biochemical and cellular approach reveals Zn<sup>2+</sup>-dependent hetero- and homodimeric CD4 and Lck assemblies in T cells

Antioxidant-related enzymes and peptides as biomarkers of metallic nanoparticles (eco)toxicity in the aquatic environment

Combining Native Mass Spectrometry and Proteomics to Differentiate and Map the Metalloform Landscape in Metallothioneins

Structural Characterization of Cu(I)/Zn(II)-metallothionein-3 by Ion Mobility Mass Spectrometry and Top-Down Mass Spectrometry

Nesfatin-3 possesses divalent metal ion binding properties, which remain hidden in the nucleobindin-2 precursor protein

Differentiated Zn(II) binding affinities in animal, plant, and bacterial metallothioneins define their zinc buffering capacity at physiological pZn

Differentiated Zn(II) binding affinities in animal, plant, and bacterial metallothioneins define their zinc buffering capacity at physiological pZn

Interaction patterns of methoprene-tolerant and germ cell-expressed Drosophila JH receptors suggest significant differences in their functioning

Interaction patterns of methoprene-tolerant and germ cell-expressed <i>Drosophila</i> JH receptors suggest significant differences in their functioning

Structural Characterization of Cu(I)/Zn(II)-metallothionein-3 by Ion Mobility Mass Spectrometry and Top-Down Mass Spectrometry

Calcium-assisted sortase A cleavage of SUMOylated metallothionein constructs leads to high-yield production of human MT3

Calcium-assisted sortase A cleavage of SUMOylated metallothionein constructs leads to high-yield production of human MT3

Nesfatin-3 possesses divalent metal ion binding properties, which remain hidden in the nucleobindin-2 precursor protein

An Extremely Stable Interprotein Tetrahedral Hg(Cys)4 Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH

Non-Conserved Amino Acid Residues Modulate the Thermodynamics of Zn(II) Binding to Classical ββα Zinc Finger Domains

Does one plus one always equal two? Structural differences between nesfatin-1, -2, and nesfatin-1/2

Relations between Structure and Zn(II) Binding Affinity Shed Light on the Mechanisms of Rad50 Hook Domain Functioning and Its Phosphorylation

Direct Interaction of ATP7B and LC3B Proteins Suggests a Cooperative Role of Copper Transportation and Autophagy

An Integrated Mass Spectrometry and Molecular Dynamics Simulations Approach Reveals the Spatial Organization Impact of Metal-Binding Sites on the Stability of Metal-Depleted Metallothionein-2 Species

The Bioinorganic Chemistry of Mammalian Metallothioneins

HP1021 is a redox switch protein identified in Helicobacter pylori

A guide to good practice in chemometric methods for vibrational spectroscopy, electrochemistry, and hyphenated mass spectrometry

Collaborators (23)

Marek Luczkowski

Michał Padjasek

Eva Freisinger

Karolina Szaro

Tomáš Do

Wiktor Koźmiński

Magdalena Matczuk

Lothar Rink

Marketa Vaculovicova

Ondrej Zitka

Stephan Clemens

Joanna Wątły

Carmen Domene

Aleksander Czogalla

Lars Hemmingsen

Roman Guran

Andrzej Ożyhar

Adam Pomorski

Beata Greb-Markiewicz

Anna Pawlik

Inga Wessels

Perdita Barran

Katarzyna Kluska

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